Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones
Selective degradation of proteins in the cell occurs through ubiquitination, which consists of post-translational deposition of ubiquitin on proteins to target them for degradation by proteases. However, ubiquitination does not only impact on protein stability, but promotes changes in their function...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fpls.2017.02274/full |
| _version_ | 1819058977162395648 |
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| author | Eduardo March Sara Farrona |
| author_facet | Eduardo March Sara Farrona |
| author_sort | Eduardo March |
| collection | DOAJ |
| description | Selective degradation of proteins in the cell occurs through ubiquitination, which consists of post-translational deposition of ubiquitin on proteins to target them for degradation by proteases. However, ubiquitination does not only impact on protein stability, but promotes changes in their functions. Whereas the deposition of ubiquitin has been amply studied and discussed, the antagonistic activity, deubiquitination, is just emerging and the full model and players involved in this mechanism are far from being completely understood. Nevertheless, it is the dynamic balance between ubiquitination and deubiquitination that is essential for the development and homeostasis of organisms. In this review, we present a detailed analysis of the members of the deubiquitinase (DUB) superfamily in plants and its division in different clades. We describe current knowledge in the molecular and functional characterisation of DUB proteins, focusing primarily on Arabidopsis thaliana. In addition, the striking function of the duality between ubiquitination and deubiquitination in the control of gene expression through the modification of chromatin is discussed and, using the available information of the activities of the DUB superfamily in yeast and animals as scaffold, we propose possible scenarios for the role of these proteins in plants. |
| first_indexed | 2024-12-21T14:03:46Z |
| format | Article |
| id | doaj.art-f669084225064e4e8ccb870f5bdbde2f |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-21T14:03:46Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-f669084225064e4e8ccb870f5bdbde2f2022-12-21T19:01:17ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2018-01-01810.3389/fpls.2017.02274329361Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of HistonesEduardo MarchSara FarronaSelective degradation of proteins in the cell occurs through ubiquitination, which consists of post-translational deposition of ubiquitin on proteins to target them for degradation by proteases. However, ubiquitination does not only impact on protein stability, but promotes changes in their functions. Whereas the deposition of ubiquitin has been amply studied and discussed, the antagonistic activity, deubiquitination, is just emerging and the full model and players involved in this mechanism are far from being completely understood. Nevertheless, it is the dynamic balance between ubiquitination and deubiquitination that is essential for the development and homeostasis of organisms. In this review, we present a detailed analysis of the members of the deubiquitinase (DUB) superfamily in plants and its division in different clades. We describe current knowledge in the molecular and functional characterisation of DUB proteins, focusing primarily on Arabidopsis thaliana. In addition, the striking function of the duality between ubiquitination and deubiquitination in the control of gene expression through the modification of chromatin is discussed and, using the available information of the activities of the DUB superfamily in yeast and animals as scaffold, we propose possible scenarios for the role of these proteins in plants.http://journal.frontiersin.org/article/10.3389/fpls.2017.02274/fulldeubiquitinationubiquitinepigeneticschromatinhistone modificationsgene expression |
| spellingShingle | Eduardo March Sara Farrona Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones Frontiers in Plant Science deubiquitination ubiquitin epigenetics chromatin histone modifications gene expression |
| title | Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones |
| title_full | Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones |
| title_fullStr | Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones |
| title_full_unstemmed | Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones |
| title_short | Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones |
| title_sort | plant deubiquitinases and their role in the control of gene expression through modification of histones |
| topic | deubiquitination ubiquitin epigenetics chromatin histone modifications gene expression |
| url | http://journal.frontiersin.org/article/10.3389/fpls.2017.02274/full |
| work_keys_str_mv | AT eduardomarch plantdeubiquitinasesandtheirroleinthecontrolofgeneexpressionthroughmodificationofhistones AT sarafarrona plantdeubiquitinasesandtheirroleinthecontrolofgeneexpressionthroughmodificationofhistones |