Association of Anti-TPO Antibodies with Insulin Resistance in Patients of Hypothyroidism with Metabolic Syndrome: A Cross-sectional Study
Introduction: Hypothyroidism and Metabolic Syndrome (MetS) are associated with insulin resistance. Exact reason for development of insulin resistance in hypothyroidism is still unclear. Aim: To determine the association between Anti-Thyroid Peroxidase Antibodies (Anti-TPO Abs) and Thyroid Stimul...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2020-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/14123/45695_CE[Ra1]_F(KM)_PF1(AG_KM)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
| Summary: | Introduction: Hypothyroidism and Metabolic Syndrome (MetS) are
associated with insulin resistance. Exact reason for development
of insulin resistance in hypothyroidism is still unclear.
Aim: To determine the association between Anti-Thyroid
Peroxidase Antibodies (Anti-TPO Abs) and Thyroid Stimulating
Hormone (TSH) with components of MetS, Fasting Insulin
(FSI) and Homeostatic Model Assessment Index for Insulin
Resistance (HOMA-IR).
Materials and Methods: Total 118 subjects of hypothyroidism
were included in this cross-sectional study. The diagnosis of
MetS was made based on National Cholesterol Education
Program Adult Treatment Panel III (NCEP ATP III) criteria.
Independent association of components of MetS, FSI and
HOMA-IR with TSH and anti-TPO Abs was analysed by
multivariate linear regression analysis.
Results: MetS was more prevalent in subclinical hyperthyroidism
(53.0%) compared to overt hypothyroidism (49.3%). Serum antiTPO Abs level was significantly high in MetS group compared
to non-MetS group in both overt (200.0±170.2 and 122.8±98.9,
p=0.02*) and subclinical (184.9±142.9 and 114.5±90.9,
p=0.04*) hyperthyroidism. Waist Circumference (WC), Fasting
Plasma Glucose (FPG), FSI and HOMA-IR were independently
associated with anti-TPO Abs in both overt and subclinical
hypothyroidism. Anti-TPO was also increased significantly
in linear trend along with increased in the number of MetS
components in both overt and subclinical hypothyroidism.
Conclusion: MetS is highly prevalent in hypothyroidism and
anti-TPO Abs rather than TSH and is more associated with
insulin resistance in patients of hypothyroidism with MetS. |
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| ISSN: | 2249-782X 0973-709X |