Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study
Objective Smoking is considered as a growing epidemic worldwide, and it was found to have negative influence on health, causing a variety of diseases in both sexes, such as pulmonary fibrosis, chronic obstructive pulmonary disease, cerebrovascular and cardiovascular disorders, pulmonary and extrapul...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=1;spage=124;epage=127;aulast=El |
| _version_ | 1818956814678491136 |
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| author | Mohamed A.A El Salam Shady Zaki Mohamed S Mousa Ahmed Motawi |
| author_facet | Mohamed A.A El Salam Shady Zaki Mohamed S Mousa Ahmed Motawi |
| author_sort | Mohamed A.A El Salam |
| collection | DOAJ |
| description | Objective Smoking is considered as a growing epidemic worldwide, and it was found to have negative influence on health, causing a variety of diseases in both sexes, such as pulmonary fibrosis, chronic obstructive pulmonary disease, cerebrovascular and cardiovascular disorders, pulmonary and extrapulmonary malignancies, infertility, erectile dysfunction, recurrent abortions, and teratogenicity. In addition, several studies have been conducted owing to concerns on its effect on the endocrinal system in males, especially its effects on testosterone levels; however, this concern is still debatable, and all reported results were conflicting.
Patients and methods Herein, the cohort study was conducted on a subgroup of smoking males (n=155) to evaluate its effect on serum total testosterone (T), estradiol (E2), as well as T/E2 ratio compared with a non-smoking control group (n=134).
Results Our results have shown that there was a significant statistical difference between smoker and non-smoker groups concerning serum total testosterone (T), estradiol (E2), and subsequently T/E2 ratio, with P values of 0.002, less than 0.001, and less than 0.001, respectively. In addition, there was a statistically significant negative correlation between the duration of smoking and T. However, there was no correlation between duration of smoking and either E2 or T/E2 ratio.
Conclusion Thus, the current study added further evidence to the unsettled debate suggesting negative harmful effects of smoking on serum testosterone level. |
| first_indexed | 2024-12-20T10:59:56Z |
| format | Article |
| id | doaj.art-f66e3430ce354ad9b7840a1b41f74b5f |
| institution | Directory Open Access Journal |
| issn | 0422-7638 2090-9950 |
| language | English |
| last_indexed | 2024-12-20T10:59:56Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-f66e3430ce354ad9b7840a1b41f74b5f2022-12-21T19:43:03ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382090-99502021-01-0170112412710.4103/ejcdt.ejcdt_61_20Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional studyMohamed A.A El SalamShady ZakiMohamed S MousaAhmed MotawiObjective Smoking is considered as a growing epidemic worldwide, and it was found to have negative influence on health, causing a variety of diseases in both sexes, such as pulmonary fibrosis, chronic obstructive pulmonary disease, cerebrovascular and cardiovascular disorders, pulmonary and extrapulmonary malignancies, infertility, erectile dysfunction, recurrent abortions, and teratogenicity. In addition, several studies have been conducted owing to concerns on its effect on the endocrinal system in males, especially its effects on testosterone levels; however, this concern is still debatable, and all reported results were conflicting. Patients and methods Herein, the cohort study was conducted on a subgroup of smoking males (n=155) to evaluate its effect on serum total testosterone (T), estradiol (E2), as well as T/E2 ratio compared with a non-smoking control group (n=134). Results Our results have shown that there was a significant statistical difference between smoker and non-smoker groups concerning serum total testosterone (T), estradiol (E2), and subsequently T/E2 ratio, with P values of 0.002, less than 0.001, and less than 0.001, respectively. In addition, there was a statistically significant negative correlation between the duration of smoking and T. However, there was no correlation between duration of smoking and either E2 or T/E2 ratio. Conclusion Thus, the current study added further evidence to the unsettled debate suggesting negative harmful effects of smoking on serum testosterone level.http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=1;spage=124;epage=127;aulast=Elcigarette smokingestradiolhormoneshypogonadismtestosterone |
| spellingShingle | Mohamed A.A El Salam Shady Zaki Mohamed S Mousa Ahmed Motawi Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study Egyptian Journal of Chest Disease and Tuberculosis cigarette smoking estradiol hormones hypogonadism testosterone |
| title | Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study |
| title_full | Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study |
| title_fullStr | Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study |
| title_full_unstemmed | Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study |
| title_short | Effect of cigarette smoking on serum testosterone level among male smokers: a cross-sectional study |
| title_sort | effect of cigarette smoking on serum testosterone level among male smokers a cross sectional study |
| topic | cigarette smoking estradiol hormones hypogonadism testosterone |
| url | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=1;spage=124;epage=127;aulast=El |
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