Chemically defined and small molecules-based generation of sinoatrial node-like cells

Chemically defined and small molecules-based generation of sinoatrial node-like cells

Abstract Background Existing methods for in vitro differentiation of human pluripotent stem cells (hPSCs) into sinoatrial node-like cells (SANLCs) require complex and undefined medium constituents. This might hinder the elucidation of the molecular mechanisms involved in cardiac subtype specificatio...

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Bibliographic Details
Main Authors: Xiaojie Hou, Shuhong Ma, Wei Fan, Fang Li, Miaomiao Xu, Chao Yang, Feng Liu, Ying Yan, Juyi Wan, Feng Lan, Bin Liao
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Stem Cell Research & Therapy
Subjects:
Human pluripotent stem cells
Sinoatrial node-like cells
Differentiation
Chemically defined medium
Small molecule
Signaling pathway
Online Access:https://doi.org/10.1186/s13287-022-02834-y

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