Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma
Abstract Background Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively in...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-018-1336-3 |
| _version_ | 1819319612212248576 |
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| author | Daixing Hu Jing Zhou Wei He Jie Peng Yijia Cao Haoyu Ren Yu Mao Yi Dou Wei Xiong Qi Xiao Xinliang Su |
| author_facet | Daixing Hu Jing Zhou Wei He Jie Peng Yijia Cao Haoyu Ren Yu Mao Yi Dou Wei Xiong Qi Xiao Xinliang Su |
| author_sort | Daixing Hu |
| collection | DOAJ |
| description | Abstract Background Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. Methods We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection. Results The rates of CLN and LLN metastases were 68.2 and 47.4%, respectively. Large tumor size (> 20 mm) had a fourfold higher risk of LLN metastasis compared with small tumor size (≤ 20 mm; OR = 4.082, 95% CI 2.646–6.289; P = 0.001). Patients with tumor in the upper lobe had ~ 3-fold higher risk of LLN metastasis compared with patients with tumor in other locations (OR = 2.874, 95% CI 1.916–4.310; P = 0.001). Multifocality and extrathyroidal extension indicated a twofold higher risk of LLN metastasis. Having ≥ 2 CLN metastases dramatically increased the risk of LLN metastasis, compared with those with < 2 CLN metastases (OR = 6.536, 95% CI 4.630–9.259; P = 0.001). Conclusions Large tumor size (> 20 mm), tumor located in the upper lobe, multifocality, extrathyroidal extension, and ≥ 2 CLN metastases may increase the risk of LLN metastasis in cN0 PTC patients. |
| first_indexed | 2024-12-24T11:06:27Z |
| format | Article |
| id | doaj.art-f672846bf6874d24b4bfecc22c42ad4e |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-24T11:06:27Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-f672846bf6874d24b4bfecc22c42ad4e2022-12-21T16:58:37ZengBMCWorld Journal of Surgical Oncology1477-78192018-02-011611610.1186/s12957-018-1336-3Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinomaDaixing Hu0Jing Zhou1Wei He2Jie Peng3Yijia Cao4Haoyu Ren5Yu Mao6Yi Dou7Wei Xiong8Qi Xiao9Xinliang Su10Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. Methods We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection. Results The rates of CLN and LLN metastases were 68.2 and 47.4%, respectively. Large tumor size (> 20 mm) had a fourfold higher risk of LLN metastasis compared with small tumor size (≤ 20 mm; OR = 4.082, 95% CI 2.646–6.289; P = 0.001). Patients with tumor in the upper lobe had ~ 3-fold higher risk of LLN metastasis compared with patients with tumor in other locations (OR = 2.874, 95% CI 1.916–4.310; P = 0.001). Multifocality and extrathyroidal extension indicated a twofold higher risk of LLN metastasis. Having ≥ 2 CLN metastases dramatically increased the risk of LLN metastasis, compared with those with < 2 CLN metastases (OR = 6.536, 95% CI 4.630–9.259; P = 0.001). Conclusions Large tumor size (> 20 mm), tumor located in the upper lobe, multifocality, extrathyroidal extension, and ≥ 2 CLN metastases may increase the risk of LLN metastasis in cN0 PTC patients.http://link.springer.com/article/10.1186/s12957-018-1336-3Papillary thyroid carcinomaCentral lymph node dissectionLateral lymph node dissectionClinical lymph node negative |
| spellingShingle | Daixing Hu Jing Zhou Wei He Jie Peng Yijia Cao Haoyu Ren Yu Mao Yi Dou Wei Xiong Qi Xiao Xinliang Su Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma World Journal of Surgical Oncology Papillary thyroid carcinoma Central lymph node dissection Lateral lymph node dissection Clinical lymph node negative |
| title | Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma |
| title_full | Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma |
| title_fullStr | Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma |
| title_full_unstemmed | Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma |
| title_short | Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma |
| title_sort | risk factors of lateral lymph node metastasis in cn0 papillary thyroid carcinoma |
| topic | Papillary thyroid carcinoma Central lymph node dissection Lateral lymph node dissection Clinical lymph node negative |
| url | http://link.springer.com/article/10.1186/s12957-018-1336-3 |
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