Current Development of Nano-Drug Delivery to Target Macrophages
Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macroph...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/5/1203 |
| _version_ | 1797501344740802560 |
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| author | Donglin Cai Wendong Gao Zhelun Li Yufeng Zhang Lan Xiao Yin Xiao |
| author_facet | Donglin Cai Wendong Gao Zhelun Li Yufeng Zhang Lan Xiao Yin Xiao |
| author_sort | Donglin Cai |
| collection | DOAJ |
| description | Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. In this review, the interactions between NPs and the immune system are introduced to help understand the pharmacokinetics and biodistribution of NPs in immune cells. The current design and strategy of NPs modification for specific macrophage-targeting are investigated and summarized. |
| first_indexed | 2024-03-10T03:17:03Z |
| format | Article |
| id | doaj.art-f67688d9869546eaa56d12e731efd1dd |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:17:03Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f67688d9869546eaa56d12e731efd1dd2023-11-23T10:12:33ZengMDPI AGBiomedicines2227-90592022-05-01105120310.3390/biomedicines10051203Current Development of Nano-Drug Delivery to Target MacrophagesDonglin Cai0Wendong Gao1Zhelun Li2Yufeng Zhang3Lan Xiao4Yin Xiao5Centre for Biomedical Technologies, School of Mechanical, Medical & Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4000, AustraliaCentre for Biomedical Technologies, School of Mechanical, Medical & Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4000, AustraliaCentre for Biomedical Technologies, School of Mechanical, Medical & Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4000, AustraliaState Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaCentre for Biomedical Technologies, School of Mechanical, Medical & Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4000, AustraliaCentre for Biomedical Technologies, School of Mechanical, Medical & Process Engineering, Queensland University of Technology (QUT), Brisbane, QLD 4000, AustraliaMacrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. In this review, the interactions between NPs and the immune system are introduced to help understand the pharmacokinetics and biodistribution of NPs in immune cells. The current design and strategy of NPs modification for specific macrophage-targeting are investigated and summarized.https://www.mdpi.com/2227-9059/10/5/1203macrophagesnanoparticlesnanotechnologydrug-targetinginflammationinflammatory diseases |
| spellingShingle | Donglin Cai Wendong Gao Zhelun Li Yufeng Zhang Lan Xiao Yin Xiao Current Development of Nano-Drug Delivery to Target Macrophages Biomedicines macrophages nanoparticles nanotechnology drug-targeting inflammation inflammatory diseases |
| title | Current Development of Nano-Drug Delivery to Target Macrophages |
| title_full | Current Development of Nano-Drug Delivery to Target Macrophages |
| title_fullStr | Current Development of Nano-Drug Delivery to Target Macrophages |
| title_full_unstemmed | Current Development of Nano-Drug Delivery to Target Macrophages |
| title_short | Current Development of Nano-Drug Delivery to Target Macrophages |
| title_sort | current development of nano drug delivery to target macrophages |
| topic | macrophages nanoparticles nanotechnology drug-targeting inflammation inflammatory diseases |
| url | https://www.mdpi.com/2227-9059/10/5/1203 |
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