Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold
Hydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/12/785 |
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| author | Sayaka Miura Rio Yamagishi Riku Miyazaki Kaori Yasuda Yuki Kawano Yoshiyuki Yokoyama Naoto Sugino Takao Kameda Satoshi Takei |
| author_facet | Sayaka Miura Rio Yamagishi Riku Miyazaki Kaori Yasuda Yuki Kawano Yoshiyuki Yokoyama Naoto Sugino Takao Kameda Satoshi Takei |
| author_sort | Sayaka Miura |
| collection | DOAJ |
| description | Hydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile solvents in the imprint materials cause transfer failure in the conventional water impermeable molds of quartz and metal. However, the water permeable mold allows the use of 67 wt% dilution water with high solubility to increase the fluidity of the hydrolyzed hyaluronic acid during the patterning of high-resolution fine microneedles for cosmetics and pharmaceuticals. This demonstration sets a new paradigm of functional pure gels for high-resolution nano-patterning applications with various cosmetic and pharmaceutical materials containing dilution water using a water permeable mold. |
| first_indexed | 2024-03-09T16:31:55Z |
| format | Article |
| id | doaj.art-f67990cfde63469e9330cd012e31536d |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T16:31:55Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-f67990cfde63469e9330cd012e31536d2023-11-24T15:00:59ZengMDPI AGGels2310-28612022-11-0181278510.3390/gels8120785Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable MoldSayaka Miura0Rio Yamagishi1Riku Miyazaki2Kaori Yasuda3Yuki Kawano4Yoshiyuki Yokoyama5Naoto Sugino6Takao Kameda7Satoshi Takei8Department of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, JapanDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, JapanDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, JapanDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, JapanToyama Industrial Technology Research and Development Center, Takaoka, Toyama 933-0981, JapanToyama Industrial Technology Research and Development Center, Takaoka, Toyama 933-0981, JapanFuturistic Technology Department, Sanko Gosei, Nanto, Toyama 939-1852, JapanFuturistic Technology Department, Sanko Gosei, Nanto, Toyama 939-1852, JapanDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, JapanHydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile solvents in the imprint materials cause transfer failure in the conventional water impermeable molds of quartz and metal. However, the water permeable mold allows the use of 67 wt% dilution water with high solubility to increase the fluidity of the hydrolyzed hyaluronic acid during the patterning of high-resolution fine microneedles for cosmetics and pharmaceuticals. This demonstration sets a new paradigm of functional pure gels for high-resolution nano-patterning applications with various cosmetic and pharmaceutical materials containing dilution water using a water permeable mold.https://www.mdpi.com/2310-2861/8/12/785fine microneedleshydrolyzed hyaluronic acidfunctional gelscosmeticstransdermal drug delivery systemwater permeable mold |
| spellingShingle | Sayaka Miura Rio Yamagishi Riku Miyazaki Kaori Yasuda Yuki Kawano Yoshiyuki Yokoyama Naoto Sugino Takao Kameda Satoshi Takei Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold Gels fine microneedles hydrolyzed hyaluronic acid functional gels cosmetics transdermal drug delivery system water permeable mold |
| title | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
| title_full | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
| title_fullStr | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
| title_full_unstemmed | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
| title_short | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
| title_sort | fabrication of high resolution fine microneedles derived from hydrolyzed hyaluronic acid gels in vacuum environment imprinting using water permeable mold |
| topic | fine microneedles hydrolyzed hyaluronic acid functional gels cosmetics transdermal drug delivery system water permeable mold |
| url | https://www.mdpi.com/2310-2861/8/12/785 |
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