How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report
<p>Abstract</p> <p>Background</p> <p>An increasing number of publications are suggesting that galectin-3 (Gal-3) and soluble cadherin fragments, such as E-cadherin (sE-CAD) and N-cadherin (sN-CAD), may be considered as cancer markers. Despite the promising results of th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-02-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://www.diagnosticpathology.org/content/7/1/17 |
| _version_ | 1818790893595918336 |
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| author | Giebultowicz Joanna Polanska-Plachta Malgorzata Wroczynski Piotr Zaborowski Piotr Polanski Jerzy A |
| author_facet | Giebultowicz Joanna Polanska-Plachta Malgorzata Wroczynski Piotr Zaborowski Piotr Polanski Jerzy A |
| author_sort | Giebultowicz Joanna |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>An increasing number of publications are suggesting that galectin-3 (Gal-3) and soluble cadherin fragments, such as E-cadherin (sE-CAD) and N-cadherin (sN-CAD), may be considered as cancer markers. Despite the promising results of the studies, there are no data concerning their levels in the plasma of echinococcosis patients. In most cases, echinoccocosis affects the liver, and its symptoms and disease course are very similar to those of liver cancer. The aim of the present study was to observe whether echinococcosis affects the concentration of soluble sN-CAD, sE-CAD fragments and Gal-3 in plasma and to determine which of them could be considered reliable liver cancer markers for further research.</p> <p>Methods</p> <p>The concentrations of sN-CAD, sE-CAD and Gal-3 in the EDTA plasma of patients suffering from echinococcosis (<it>N = 20</it>), liver cancers (<it>N = 10</it>) and healthy subjects (<it>N = 20</it>) were measured using the ELISA method.</p> <p>Results</p> <p>The plasma concentration of sE-CAD was lower (<it>p = 0.0381</it>), and that of Gal-3 higher (<it>p = 0.0288</it>), in echinococcosis than in the healthy group. However, only the concentration of sE-CAD differed significantly among the three analysed groups. In echinococcosis there was a correlation between the sE-CAD and CRP levels (<it>rs = 0.79</it>; <it>p = 0.0066</it>) as well as a correlation between the sE-CAD level and the number of leukocytes (<it>rs = 0.65</it>; <it>p = 0.0210</it>) in the blood.</p> <p>Conclusions</p> <p>Echinococcosis affects the concentration of soluble sE-CAD fragments and Gal-3 in plasma. sE-CAD can be considered as a marker for differentiation between liver cancer and echinoccocossis, a parasitic liver disease similar in symptoms. Further study is required to confirm these preliminary results.</p> <p>Virtual Slides</p> <p>The virtual slide(s) for this article can be found here:</p> <p><url>http://www.diagnosticpathology.diagnomx.eu/vs/2115657402650448</url>.</p> |
| first_indexed | 2024-12-18T15:02:42Z |
| format | Article |
| id | doaj.art-f67aca0dfca147a2a70ca03002117ce0 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-18T15:02:42Z |
| publishDate | 2012-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-f67aca0dfca147a2a70ca03002117ce02022-12-21T21:03:52ZengBMCDiagnostic Pathology1746-15962012-02-01711710.1186/1746-1596-7-17How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary reportGiebultowicz JoannaPolanska-Plachta MalgorzataWroczynski PiotrZaborowski PiotrPolanski Jerzy A<p>Abstract</p> <p>Background</p> <p>An increasing number of publications are suggesting that galectin-3 (Gal-3) and soluble cadherin fragments, such as E-cadherin (sE-CAD) and N-cadherin (sN-CAD), may be considered as cancer markers. Despite the promising results of the studies, there are no data concerning their levels in the plasma of echinococcosis patients. In most cases, echinoccocosis affects the liver, and its symptoms and disease course are very similar to those of liver cancer. The aim of the present study was to observe whether echinococcosis affects the concentration of soluble sN-CAD, sE-CAD fragments and Gal-3 in plasma and to determine which of them could be considered reliable liver cancer markers for further research.</p> <p>Methods</p> <p>The concentrations of sN-CAD, sE-CAD and Gal-3 in the EDTA plasma of patients suffering from echinococcosis (<it>N = 20</it>), liver cancers (<it>N = 10</it>) and healthy subjects (<it>N = 20</it>) were measured using the ELISA method.</p> <p>Results</p> <p>The plasma concentration of sE-CAD was lower (<it>p = 0.0381</it>), and that of Gal-3 higher (<it>p = 0.0288</it>), in echinococcosis than in the healthy group. However, only the concentration of sE-CAD differed significantly among the three analysed groups. In echinococcosis there was a correlation between the sE-CAD and CRP levels (<it>rs = 0.79</it>; <it>p = 0.0066</it>) as well as a correlation between the sE-CAD level and the number of leukocytes (<it>rs = 0.65</it>; <it>p = 0.0210</it>) in the blood.</p> <p>Conclusions</p> <p>Echinococcosis affects the concentration of soluble sE-CAD fragments and Gal-3 in plasma. sE-CAD can be considered as a marker for differentiation between liver cancer and echinoccocossis, a parasitic liver disease similar in symptoms. Further study is required to confirm these preliminary results.</p> <p>Virtual Slides</p> <p>The virtual slide(s) for this article can be found here:</p> <p><url>http://www.diagnosticpathology.diagnomx.eu/vs/2115657402650448</url>.</p>http://www.diagnosticpathology.org/content/7/1/17EchinococcosisN-cadherinE-cadherinGalectin-3Liver cancer |
| spellingShingle | Giebultowicz Joanna Polanska-Plachta Malgorzata Wroczynski Piotr Zaborowski Piotr Polanski Jerzy A How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report Diagnostic Pathology Echinococcosis N-cadherin E-cadherin Galectin-3 Liver cancer |
| title | How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report |
| title_full | How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report |
| title_fullStr | How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report |
| title_full_unstemmed | How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report |
| title_short | How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? a preliminary report |
| title_sort | how echinoccocosis affects potential cancer markers in plasma galectin 3 sn cadherin and se cadherin a preliminary report |
| topic | Echinococcosis N-cadherin E-cadherin Galectin-3 Liver cancer |
| url | http://www.diagnosticpathology.org/content/7/1/17 |
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