AML/Normal Progenitor Balance Instead of Total Tumor Load (MRD) Accounts for Prognostic Impact of Flowcytometric Residual Disease in AML

AML/Normal Progenitor Balance Instead of Total Tumor Load (MRD) Accounts for Prognostic Impact of Flowcytometric Residual Disease in AML

Measurable residual disease (MRD) in AML, assessed by multicolor flow cytometry, is an important prognostic factor. Progenitors are key populations in defining MRD, and cases of MRD involving these progenitors are calculated as percentage of WBC and referred to as white blood cell MRD (WBC-MRD). Two...

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Bibliographic Details
Main Authors: Diana Hanekamp, Jesse M. Tettero, Gert J. Ossenkoppele, Angèle Kelder, Jacqueline Cloos, Gerrit Jan Schuurhuis
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
acute myeloid leukemia
minimal/measurable residual disease
multiparameter flow cytometry
primitive compartment
prognostic value
MRD false negativity
Online Access:https://www.mdpi.com/2072-6694/13/11/2597

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