Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues

Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues

A simple approach toward the synthesis of the marine sponge derived pigment fascaplysin was used to obtain the marine alkaloids 3-bromofascaplysin and 3,10-dibromofascaplysin. These compounds were used for first syntheses of the alkaloids 14-bromoreticulatate and 14-bromoreticulatine. Preliminary bi...

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Bibliographic Details
Main Authors: Maxim E. Zhidkov, Polina A. Smirnova, Oleg A. Tryapkin, Alexey V. Kantemirov, Yuliya V. Khudyakova, Olesya S. Malyarenko, Svetlana P. Ermakova, Valeria P. Grigorchuk, Moritz Kaune, Gunhild von Amsberg, Sergey A. Dyshlovoy
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Marine Drugs
Subjects:
total synthesis
14-bromoreticulatine
3,10-dibromofascaplysin
bioactivity
Online Access:https://www.mdpi.com/1660-3397/17/9/496

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