Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy
Abstract Introduction IgA nephropathy (IgAN) is the commonest global cause of glomerulonephritis. Extent of fibrosis, tubular atrophy and glomerulosclerosis predict renal function decline. Extent of renal fibrosis is assessed with renal biopsy which is invasive and prone to sampling error. We assess...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1447-2 |
| _version_ | 1818760113641488384 |
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| author | M. P. Graham-Brown A. Singh J. Wormleighton N. J. Brunskill G. P. McCann J. Barratt J. O. Burton G. Xu |
| author_facet | M. P. Graham-Brown A. Singh J. Wormleighton N. J. Brunskill G. P. McCann J. Barratt J. O. Burton G. Xu |
| author_sort | M. P. Graham-Brown |
| collection | DOAJ |
| description | Abstract Introduction IgA nephropathy (IgAN) is the commonest global cause of glomerulonephritis. Extent of fibrosis, tubular atrophy and glomerulosclerosis predict renal function decline. Extent of renal fibrosis is assessed with renal biopsy which is invasive and prone to sampling error. We assessed the utility of non-contrast native T1 mapping of the kidney in patients with IgAN for assessment of renal fibrosis. Methods Renal native T1 mapping was undertaken in 20 patients with IgAN and 10 healthy subjects. Ten IgAN patients had a second scan to assess test-retest reproducibility of the technique. Native T1 times were compared to markers of disease severity including degree of fibrosis, eGFR, rate of eGFR decline and proteinuria. Results All patients tolerated the MRI scan and analysable quality T1 maps were acquired in at least one kidney in all subjects. Cortical T1 times were significantly longer in patients with IgAN than healthy subjects (1540 ms ± 110 ms versus 1446 ± 88 ms, p = 0.038). There was excellent test-retest reproducibility of the technique, with Coefficient-of-variability of axial and coronal T1 mapping analysis being 2.9 and 3.7% respectively. T1 correlated with eGFR and proteinuria (r = − 0.444, p = 0.016; r = 0.533, p = 0.003 respectively). Patients with an eGFR decline > 2 ml/min/year had increased T1 times compared to those with a decline < 2 ml/min/year (1615 ± 135 ms versus 1516 ± 87 ms, p = 0.068), and T1 time was also higher in patients with a histological ‘T’-score of > 0, compared to those with a ‘T’-score of 0 (1575 ± 106 ms versus 1496 ± 105 ms, p = 0.131), though not to significance. Conclusions Cortical native T1 time is significantly increased in patients with IgAN compared to healthy subjects and correlates with markers of renal disease. Reproducibility of renal T1 mapping is excellent. This study highlights the potential utility of native T1 mapping in IgAN and other progressive nephropathies, and larger prospective studies are warranted. |
| first_indexed | 2024-12-18T06:53:28Z |
| format | Article |
| id | doaj.art-f67e1308b44944528e1e53a32391219d |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-18T06:53:28Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-f67e1308b44944528e1e53a32391219d2022-12-21T21:17:16ZengBMCBMC Nephrology1471-23692019-07-012011710.1186/s12882-019-1447-2Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathyM. P. Graham-Brown0A. Singh1J. Wormleighton2N. J. Brunskill3G. P. McCann4J. Barratt5J. O. Burton6G. Xu7John Walls Renal Unit, University Hosptials of Leicester NHS TrustDeparment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Centre, Glenfield HospitalDeparment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Centre, Glenfield HospitalJohn Walls Renal Unit, University Hosptials of Leicester NHS TrustDeparment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Centre, Glenfield HospitalJohn Walls Renal Unit, University Hosptials of Leicester NHS TrustJohn Walls Renal Unit, University Hosptials of Leicester NHS TrustJohn Walls Renal Unit, University Hosptials of Leicester NHS TrustAbstract Introduction IgA nephropathy (IgAN) is the commonest global cause of glomerulonephritis. Extent of fibrosis, tubular atrophy and glomerulosclerosis predict renal function decline. Extent of renal fibrosis is assessed with renal biopsy which is invasive and prone to sampling error. We assessed the utility of non-contrast native T1 mapping of the kidney in patients with IgAN for assessment of renal fibrosis. Methods Renal native T1 mapping was undertaken in 20 patients with IgAN and 10 healthy subjects. Ten IgAN patients had a second scan to assess test-retest reproducibility of the technique. Native T1 times were compared to markers of disease severity including degree of fibrosis, eGFR, rate of eGFR decline and proteinuria. Results All patients tolerated the MRI scan and analysable quality T1 maps were acquired in at least one kidney in all subjects. Cortical T1 times were significantly longer in patients with IgAN than healthy subjects (1540 ms ± 110 ms versus 1446 ± 88 ms, p = 0.038). There was excellent test-retest reproducibility of the technique, with Coefficient-of-variability of axial and coronal T1 mapping analysis being 2.9 and 3.7% respectively. T1 correlated with eGFR and proteinuria (r = − 0.444, p = 0.016; r = 0.533, p = 0.003 respectively). Patients with an eGFR decline > 2 ml/min/year had increased T1 times compared to those with a decline < 2 ml/min/year (1615 ± 135 ms versus 1516 ± 87 ms, p = 0.068), and T1 time was also higher in patients with a histological ‘T’-score of > 0, compared to those with a ‘T’-score of 0 (1575 ± 106 ms versus 1496 ± 105 ms, p = 0.131), though not to significance. Conclusions Cortical native T1 time is significantly increased in patients with IgAN compared to healthy subjects and correlates with markers of renal disease. Reproducibility of renal T1 mapping is excellent. This study highlights the potential utility of native T1 mapping in IgAN and other progressive nephropathies, and larger prospective studies are warranted.http://link.springer.com/article/10.1186/s12882-019-1447-2IgA nephropathyRenal fibrosisNative T1 mappingMRI |
| spellingShingle | M. P. Graham-Brown A. Singh J. Wormleighton N. J. Brunskill G. P. McCann J. Barratt J. O. Burton G. Xu Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy BMC Nephrology IgA nephropathy Renal fibrosis Native T1 mapping MRI |
| title | Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy |
| title_full | Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy |
| title_fullStr | Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy |
| title_full_unstemmed | Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy |
| title_short | Association between native T1 mapping of the kidney and renal fibrosis in patients with IgA nephropathy |
| title_sort | association between native t1 mapping of the kidney and renal fibrosis in patients with iga nephropathy |
| topic | IgA nephropathy Renal fibrosis Native T1 mapping MRI |
| url | http://link.springer.com/article/10.1186/s12882-019-1447-2 |
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