Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet
Low-fat diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)], a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) in plasma, as well as small dense LDL particles. We sought to determine whether increases in plasma Lp(a) induced by a low-fat high-carbohyd...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-11-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520409666 |
| _version_ | 1818726732071436288 |
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| author | Nastaran Faghihnia Sotirios Tsimikas Elizabeth R. Miller Joseph L. Witztum Ronald M. Krauss |
| author_facet | Nastaran Faghihnia Sotirios Tsimikas Elizabeth R. Miller Joseph L. Witztum Ronald M. Krauss |
| author_sort | Nastaran Faghihnia |
| collection | DOAJ |
| description | Low-fat diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)], a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) in plasma, as well as small dense LDL particles. We sought to determine whether increases in plasma Lp(a) induced by a low-fat high-carbohydrate (LFHC) diet are related to changes in OxPL and LDL subclasses. We studied 63 healthy subjects after 4 weeks of consuming, in random order, a high-fat low-carbohydrate (HFLC) diet and a LFHC diet. Plasma concentrations of Lp(a) (P < 0.01), OxPL/apolipoprotein (apo)B (P < 0.005), and OxPL-apo(a) (P < 0.05) were significantly higher on the LFHC diet compared with the HFLC diet whereas LDL peak particle size was significantly smaller (P < 0.0001). Diet-induced changes in Lp(a) were strongly correlated with changes in OxPL/apoB (P < 0.0001). The increases in plasma Lp(a) levels after the LFHC diet were also correlated with decreases in medium LDL particles (P < 0.01) and increases in very small LDL particles (P < 0.05). These results demonstrate that induction of increased levels of Lp(a) by an LFHC diet is associated with increases in OxPLs and with changes in LDL subclass distribution that may reflect altered metabolism of Lp(a) particles. |
| first_indexed | 2024-12-17T22:02:52Z |
| format | Article |
| id | doaj.art-f67e5c5e187d4710ac8e7a59c50b2dc9 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T22:02:52Z |
| publishDate | 2010-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-f67e5c5e187d4710ac8e7a59c50b2dc92022-12-21T21:30:56ZengElsevierJournal of Lipid Research0022-22752010-11-01511133243330Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate dietNastaran Faghihnia0Sotirios Tsimikas1Elizabeth R. Miller2Joseph L. Witztum3Ronald M. Krauss4Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, CADepartment of Medicine, University of California, San Diego, La Jolla, CADepartment of Medicine, University of California, San Diego, La Jolla, CADepartment of Medicine, University of California, San Diego, La Jolla, CADepartment of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, CA; To whom correspondence should be addressed. rkrauss@chori.orgLow-fat diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)], a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) in plasma, as well as small dense LDL particles. We sought to determine whether increases in plasma Lp(a) induced by a low-fat high-carbohydrate (LFHC) diet are related to changes in OxPL and LDL subclasses. We studied 63 healthy subjects after 4 weeks of consuming, in random order, a high-fat low-carbohydrate (HFLC) diet and a LFHC diet. Plasma concentrations of Lp(a) (P < 0.01), OxPL/apolipoprotein (apo)B (P < 0.005), and OxPL-apo(a) (P < 0.05) were significantly higher on the LFHC diet compared with the HFLC diet whereas LDL peak particle size was significantly smaller (P < 0.0001). Diet-induced changes in Lp(a) were strongly correlated with changes in OxPL/apoB (P < 0.0001). The increases in plasma Lp(a) levels after the LFHC diet were also correlated with decreases in medium LDL particles (P < 0.01) and increases in very small LDL particles (P < 0.05). These results demonstrate that induction of increased levels of Lp(a) by an LFHC diet is associated with increases in OxPLs and with changes in LDL subclass distribution that may reflect altered metabolism of Lp(a) particles.http://www.sciencedirect.com/science/article/pii/S0022227520409666lipidatherosclerosiscardiovascular risklow density lipoproteindietoxidized lipids |
| spellingShingle | Nastaran Faghihnia Sotirios Tsimikas Elizabeth R. Miller Joseph L. Witztum Ronald M. Krauss Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet Journal of Lipid Research lipid atherosclerosis cardiovascular risk low density lipoprotein diet oxidized lipids |
| title | Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet |
| title_full | Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet |
| title_fullStr | Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet |
| title_full_unstemmed | Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet |
| title_short | Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet |
| title_sort | changes in lipoprotein a oxidized phospholipids and ldl subclasses with a low fat high carbohydrate diet |
| topic | lipid atherosclerosis cardiovascular risk low density lipoprotein diet oxidized lipids |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520409666 |
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