Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome.
In this study of eight rare atypical deletion cases with Williams-Beuren syndrome (WS; also known as 7q11.23 deletion syndrome) consisting of three different patterns of deletions, compared to typical WS and typically developing (TD) individuals, we show preliminary evidence of dissociable genetic c...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4126723?pdf=render |
| _version_ | 1818113124148969472 |
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| author | Fumiko Hoeft Li Dai Brian W Haas Kristen Sheau Masaru Mimura Debra Mills Albert Galaburda Ursula Bellugi Julie R Korenberg Allan L Reiss |
| author_facet | Fumiko Hoeft Li Dai Brian W Haas Kristen Sheau Masaru Mimura Debra Mills Albert Galaburda Ursula Bellugi Julie R Korenberg Allan L Reiss |
| author_sort | Fumiko Hoeft |
| collection | DOAJ |
| description | In this study of eight rare atypical deletion cases with Williams-Beuren syndrome (WS; also known as 7q11.23 deletion syndrome) consisting of three different patterns of deletions, compared to typical WS and typically developing (TD) individuals, we show preliminary evidence of dissociable genetic contributions to brain structure and human cognition. Univariate and multivariate pattern classification results of morphometric brain patterns complemented by behavior implicate a possible role for the chromosomal region that includes: 1) GTF2I/GTF2IRD1 in visuo-spatial/motor integration, intraparietal as well as overall gray matter structures, 2) the region spanning ABHD11 through RFC2 including LIMK1, in social cognition, in particular approachability, as well as orbitofrontal, amygdala and fusiform anatomy, and 3) the regions including STX1A, and/or CYLN2 in overall white matter structure. This knowledge contributes to our understanding of the role of genetics on human brain structure, cognition and pathophysiology of altered cognition in WS. The current study builds on ongoing research designed to characterize the impact of multiple genes, gene-gene interactions and changes in gene expression on the human brain. |
| first_indexed | 2024-12-11T03:29:50Z |
| format | Article |
| id | doaj.art-f67f43341046480a807d0360caf59faf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T03:29:50Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f67f43341046480a807d0360caf59faf2022-12-22T01:22:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10408810.1371/journal.pone.0104088Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome.Fumiko HoeftLi DaiBrian W HaasKristen SheauMasaru MimuraDebra MillsAlbert GalaburdaUrsula BellugiJulie R KorenbergAllan L ReissIn this study of eight rare atypical deletion cases with Williams-Beuren syndrome (WS; also known as 7q11.23 deletion syndrome) consisting of three different patterns of deletions, compared to typical WS and typically developing (TD) individuals, we show preliminary evidence of dissociable genetic contributions to brain structure and human cognition. Univariate and multivariate pattern classification results of morphometric brain patterns complemented by behavior implicate a possible role for the chromosomal region that includes: 1) GTF2I/GTF2IRD1 in visuo-spatial/motor integration, intraparietal as well as overall gray matter structures, 2) the region spanning ABHD11 through RFC2 including LIMK1, in social cognition, in particular approachability, as well as orbitofrontal, amygdala and fusiform anatomy, and 3) the regions including STX1A, and/or CYLN2 in overall white matter structure. This knowledge contributes to our understanding of the role of genetics on human brain structure, cognition and pathophysiology of altered cognition in WS. The current study builds on ongoing research designed to characterize the impact of multiple genes, gene-gene interactions and changes in gene expression on the human brain.http://europepmc.org/articles/PMC4126723?pdf=render |
| spellingShingle | Fumiko Hoeft Li Dai Brian W Haas Kristen Sheau Masaru Mimura Debra Mills Albert Galaburda Ursula Bellugi Julie R Korenberg Allan L Reiss Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. PLoS ONE |
| title | Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. |
| title_full | Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. |
| title_fullStr | Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. |
| title_full_unstemmed | Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. |
| title_short | Mapping genetically controlled neural circuits of social behavior and visuo-motor integration by a preliminary examination of atypical deletions with Williams syndrome. |
| title_sort | mapping genetically controlled neural circuits of social behavior and visuo motor integration by a preliminary examination of atypical deletions with williams syndrome |
| url | http://europepmc.org/articles/PMC4126723?pdf=render |
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