Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids
Background A method for periprocedural contrast agent-free visualization of uterine fibroid perfusion could potentially shorten magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) treatment times and improve outcomes. Our goal was to test feasibility of perfusion fraction mapping b...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2321980 |
| _version_ | 1826902206042865664 |
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| author | Derk J. Slotman Lambertus W. Bartels Ingrid M. Nijholt Martijn Froeling Judith A. F. Huirne Chrit T.W Moonen Martijn F. Boomsma |
| author_facet | Derk J. Slotman Lambertus W. Bartels Ingrid M. Nijholt Martijn Froeling Judith A. F. Huirne Chrit T.W Moonen Martijn F. Boomsma |
| author_sort | Derk J. Slotman |
| collection | DOAJ |
| description | Background A method for periprocedural contrast agent-free visualization of uterine fibroid perfusion could potentially shorten magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) treatment times and improve outcomes. Our goal was to test feasibility of perfusion fraction mapping by intravoxel incoherent motion (IVIM) modeling using diffusion-weighted MRI as method for visual evaluation of MR-HIFU treatment progression.Methods Conventional and T2-corrected IVIM-derived perfusion fraction maps were retrospectively calculated by applying two fitting methods to diffusion-weighted MRI data (b = 0, 50, 100, 200, 400, 600 and 800 s/mm2 at 1.5 T) from forty-four premenopausal women who underwent MR-HIFU ablation treatment of uterine fibroids. Contrast in perfusion fraction maps between areas with low perfusion fraction and surrounding tissue in the target uterine fibroid immediately following MR-HIFU treatment was evaluated. Additionally, the Dice similarity coefficient (DSC) was calculated between delineated areas with low IVIM-derived perfusion fraction and hypoperfusion based on CE-T1w.Results Average perfusion fraction ranged between 0.068 and 0.083 in areas with low perfusion fraction based on visual assessment, and between 0.256 and 0.335 in surrounding tissues (all p < 0.001). DSCs ranged from 0.714 to 0.734 between areas with low perfusion fraction and the CE-T1w derived non-perfused areas, with excellent intraobserver reliability of the delineated areas (ICC 0.97).Conclusion The MR-HIFU treatment effect in uterine fibroids can be visualized using IVIM perfusion fraction mapping, in moderate concordance with contrast enhanced MRI. IVIM perfusion fraction mapping has therefore the potential to serve as a contrast agent-free imaging method to visualize the MR-HIFU treatment progression in uterine fibroids. |
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| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2025-02-17T07:36:04Z |
| publishDate | 2024-12-01 |
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| spelling | doaj.art-f68004aaa03746dcae3b634649cba3bb2025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2321980Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroidsDerk J. Slotman0Lambertus W. Bartels1Ingrid M. Nijholt2Martijn Froeling3Judith A. F. Huirne4Chrit T.W Moonen5Martijn F. Boomsma6Department of Radiology, Isala Hospital, Zwolle, The NetherlandsImaging & Oncology Division, University Medical Center Utrecht, Utrecht, The NetherlandsDepartment of Radiology, Isala Hospital, Zwolle, The NetherlandsImaging & Oncology Division, University Medical Center Utrecht, Utrecht, The NetherlandsDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Amsterdam, The NetherlandsImaging & Oncology Division, University Medical Center Utrecht, Utrecht, The NetherlandsDepartment of Radiology, Isala Hospital, Zwolle, The NetherlandsBackground A method for periprocedural contrast agent-free visualization of uterine fibroid perfusion could potentially shorten magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) treatment times and improve outcomes. Our goal was to test feasibility of perfusion fraction mapping by intravoxel incoherent motion (IVIM) modeling using diffusion-weighted MRI as method for visual evaluation of MR-HIFU treatment progression.Methods Conventional and T2-corrected IVIM-derived perfusion fraction maps were retrospectively calculated by applying two fitting methods to diffusion-weighted MRI data (b = 0, 50, 100, 200, 400, 600 and 800 s/mm2 at 1.5 T) from forty-four premenopausal women who underwent MR-HIFU ablation treatment of uterine fibroids. Contrast in perfusion fraction maps between areas with low perfusion fraction and surrounding tissue in the target uterine fibroid immediately following MR-HIFU treatment was evaluated. Additionally, the Dice similarity coefficient (DSC) was calculated between delineated areas with low IVIM-derived perfusion fraction and hypoperfusion based on CE-T1w.Results Average perfusion fraction ranged between 0.068 and 0.083 in areas with low perfusion fraction based on visual assessment, and between 0.256 and 0.335 in surrounding tissues (all p < 0.001). DSCs ranged from 0.714 to 0.734 between areas with low perfusion fraction and the CE-T1w derived non-perfused areas, with excellent intraobserver reliability of the delineated areas (ICC 0.97).Conclusion The MR-HIFU treatment effect in uterine fibroids can be visualized using IVIM perfusion fraction mapping, in moderate concordance with contrast enhanced MRI. IVIM perfusion fraction mapping has therefore the potential to serve as a contrast agent-free imaging method to visualize the MR-HIFU treatment progression in uterine fibroids.https://www.tandfonline.com/doi/10.1080/02656736.2024.2321980High-intensity focused ultrasound ablationleiomyomamagnetic resonance imagingdiffusion weighted MRIintravoxel incoherent motion modeling (IVIM) |
| spellingShingle | Derk J. Slotman Lambertus W. Bartels Ingrid M. Nijholt Martijn Froeling Judith A. F. Huirne Chrit T.W Moonen Martijn F. Boomsma Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids International Journal of Hyperthermia High-intensity focused ultrasound ablation leiomyoma magnetic resonance imaging diffusion weighted MRI intravoxel incoherent motion modeling (IVIM) |
| title | Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids |
| title_full | Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids |
| title_fullStr | Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids |
| title_full_unstemmed | Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids |
| title_short | Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids |
| title_sort | intravoxel incoherent motion ivim derived perfusion fraction mapping for the visual evaluation of mr guided high intensity focused ultrasound mr hifu ablation of uterine fibroids |
| topic | High-intensity focused ultrasound ablation leiomyoma magnetic resonance imaging diffusion weighted MRI intravoxel incoherent motion modeling (IVIM) |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2321980 |
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