The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis
AbstractWe comprised metabolites of gut microbiota (GM; endogenous species) and dietary plant-derived natural flavonoids (DPDNFs; exogenous species) were known as potent effectors against non-alcoholic fatty liver disease (NAFLD) via network pharmacology (NP). The crucial targets against NAFLD were...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2023.2203734 |
| _version_ | 1797631162590429184 |
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| author | Ki-Kwang Oh Haripriya Gupta Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Su-Been Lee Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Byeong-Hyun Min Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Mi-Ran Choi Dong Joon Kim Ki-Tae Suk |
| author_facet | Ki-Kwang Oh Haripriya Gupta Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Su-Been Lee Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Byeong-Hyun Min Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Mi-Ran Choi Dong Joon Kim Ki-Tae Suk |
| author_sort | Ki-Kwang Oh |
| collection | DOAJ |
| description | AbstractWe comprised metabolites of gut microbiota (GM; endogenous species) and dietary plant-derived natural flavonoids (DPDNFs; exogenous species) were known as potent effectors against non-alcoholic fatty liver disease (NAFLD) via network pharmacology (NP). The crucial targets against NAFLD were identified via GM and DPDNFs. The protein interaction (PPI), bubble chart and networks of GM or natural products- metabolites-targets-key signalling (GNMTK) pathway were described via R Package. Furthermore, the molecular docking test (MDT) to verify the affinity was performed between metabolite(s) and target(s) on a key signalling pathway. On the networks of GNMTK, Enterococcus sp. 45, Escherichia sp.12, Escherichia sp.33 and Bacterium MRG-PMF-1 as key microbiota; flavonoid-rich products as key natural resources; luteolin and myricetin as key metabolites (or dietary flavonoids); AKT Serine/Threonine Kinase 1 (AKT1), CF Transmembrane conductance Regulator (CFTR) and PhosphoInositide-3-Kinase, Regulatory subunit 1 (PIK3R1) as key targets are promising components to treat NAFLD, by suppressing cyclic Adenosine MonoPhosphate (cAMP) signalling pathway. This study shows that components (microbiota, metabolites, targets and a key signalling pathway) and DPDNFs can exert combinatorial pharmacological effects against NAFLD. Overall, the integrated pharmacological approach sheds light on the relationships between GM and DPDNFs. |
| first_indexed | 2024-03-11T11:18:01Z |
| format | Article |
| id | doaj.art-f6809733c1a34a9da9af261124cd091f |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-11T11:18:01Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-f6809733c1a34a9da9af261124cd091f2023-11-10T17:19:33ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2023-12-0151121723210.1080/21691401.2023.2203734The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysisKi-Kwang Oh0Haripriya Gupta1Raja Ganesan2Satya Priya Sharma3Sung-Min Won4Jin-Ju Jeong5Su-Been Lee6Min-Gi Cha7Goo-Hyun Kwon8Min-Kyo Jeong9Byeong-Hyun Min10Ji-Ye Hyun11Jung-A Eom12Hee-Jin Park13Sang-Jun Yoon14Mi-Ran Choi15Dong Joon Kim16Ki-Tae Suk17Center for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaCenter for Microbiome, Institute for Liver and Digestive Diseases, Hallym University Medical Center, Chuncheon, KoreaAbstractWe comprised metabolites of gut microbiota (GM; endogenous species) and dietary plant-derived natural flavonoids (DPDNFs; exogenous species) were known as potent effectors against non-alcoholic fatty liver disease (NAFLD) via network pharmacology (NP). The crucial targets against NAFLD were identified via GM and DPDNFs. The protein interaction (PPI), bubble chart and networks of GM or natural products- metabolites-targets-key signalling (GNMTK) pathway were described via R Package. Furthermore, the molecular docking test (MDT) to verify the affinity was performed between metabolite(s) and target(s) on a key signalling pathway. On the networks of GNMTK, Enterococcus sp. 45, Escherichia sp.12, Escherichia sp.33 and Bacterium MRG-PMF-1 as key microbiota; flavonoid-rich products as key natural resources; luteolin and myricetin as key metabolites (or dietary flavonoids); AKT Serine/Threonine Kinase 1 (AKT1), CF Transmembrane conductance Regulator (CFTR) and PhosphoInositide-3-Kinase, Regulatory subunit 1 (PIK3R1) as key targets are promising components to treat NAFLD, by suppressing cyclic Adenosine MonoPhosphate (cAMP) signalling pathway. This study shows that components (microbiota, metabolites, targets and a key signalling pathway) and DPDNFs can exert combinatorial pharmacological effects against NAFLD. Overall, the integrated pharmacological approach sheds light on the relationships between GM and DPDNFs.https://www.tandfonline.com/doi/10.1080/21691401.2023.2203734gut microbiotadietary plant-derived natural flavonoidsnon-alcoholic fatty liver diseasenetwork pharmacologycAMP signalling pathwaycombinatorial pharmacological effects |
| spellingShingle | Ki-Kwang Oh Haripriya Gupta Raja Ganesan Satya Priya Sharma Sung-Min Won Jin-Ju Jeong Su-Been Lee Min-Gi Cha Goo-Hyun Kwon Min-Kyo Jeong Byeong-Hyun Min Ji-Ye Hyun Jung-A Eom Hee-Jin Park Sang-Jun Yoon Mi-Ran Choi Dong Joon Kim Ki-Tae Suk The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis Artificial Cells, Nanomedicine, and Biotechnology gut microbiota dietary plant-derived natural flavonoids non-alcoholic fatty liver disease network pharmacology cAMP signalling pathway combinatorial pharmacological effects |
| title | The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis |
| title_full | The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis |
| title_fullStr | The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis |
| title_full_unstemmed | The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis |
| title_short | The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis |
| title_sort | seamless integration of dietary plant derived natural flavonoids and gut microbiota may ameliorate non alcoholic fatty liver disease a network pharmacology analysis |
| topic | gut microbiota dietary plant-derived natural flavonoids non-alcoholic fatty liver disease network pharmacology cAMP signalling pathway combinatorial pharmacological effects |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2023.2203734 |
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