P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS
Background: Zero flow pressure (P∞), the steady-state pressure following cardiac arrest or cessation of flow is often assumed to equal mean circulatory filling pressure (MCFP). [1] However, this assumes complete equilibration of circulatory pressures, which may not occur if there is a ‘critical clos...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930046/view |
| _version_ | 1818006228379369472 |
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| author | Alun Hughes Kim Parker Ashraf Khir |
| author_facet | Alun Hughes Kim Parker Ashraf Khir |
| author_sort | Alun Hughes |
| collection | DOAJ |
| description | Background: Zero flow pressure (P∞), the steady-state pressure following cardiac arrest or cessation of flow is often assumed to equal mean circulatory filling pressure (MCFP). [1] However, this assumes complete equilibration of circulatory pressures, which may not occur if there is a ‘critical closing pressure’ or ‘Waterfall’ in the circulation. We undertook a systematic review and meta-analysis to obtain robust estimates of P∞ and compared this with MCFP measured in the same studies.
Methods: A literature search was performed using PubMed and was limited to full articles in English using the search terms "mean circulatory filling pressure” OR "critical closing” OR "zero-flow". Only data relating to measurements of pressure following cardiac arrest or cessation of blood flow were included. Other exclusions were: individual case-reports, pregnancy, non-adult animals, not mammalian, or any non-human models of disease. Meta-analysis was performed using a random effects model in Stata 15.1. Data are mean (95% confidence intervals).
Results: A total of 1082 unique publications were identified; 1062 were excluded during screening. The remaining 20 studies with P∞ data were used to perform a meta-analysis. These included data from dog, rat, pig and human; 8 of these articles also provided data on MCFP. From this analysis P∞ = 26.5(23.4, 29.5) mmHg (n = 20) and the difference between P∞ and MCFP was 15.1(12.0, 18.3) mmHg (n = 8).
Conclusions: P∞ and MCFP differ substantially, indicating non-equilibration of pressures in the circulation following cessation of flow at least in the short-term (seconds to minutes). |
| first_indexed | 2024-04-14T04:58:24Z |
| format | Article |
| id | doaj.art-f680f3a3f8b4451e836cb5ef59dbabc5 |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-14T04:58:24Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-f680f3a3f8b4451e836cb5ef59dbabc52022-12-22T02:11:06ZengBMCArtery Research1876-44012018-12-012410.1016/j.artres.2018.10.106P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSISAlun HughesKim ParkerAshraf KhirBackground: Zero flow pressure (P∞), the steady-state pressure following cardiac arrest or cessation of flow is often assumed to equal mean circulatory filling pressure (MCFP). [1] However, this assumes complete equilibration of circulatory pressures, which may not occur if there is a ‘critical closing pressure’ or ‘Waterfall’ in the circulation. We undertook a systematic review and meta-analysis to obtain robust estimates of P∞ and compared this with MCFP measured in the same studies. Methods: A literature search was performed using PubMed and was limited to full articles in English using the search terms "mean circulatory filling pressure” OR "critical closing” OR "zero-flow". Only data relating to measurements of pressure following cardiac arrest or cessation of blood flow were included. Other exclusions were: individual case-reports, pregnancy, non-adult animals, not mammalian, or any non-human models of disease. Meta-analysis was performed using a random effects model in Stata 15.1. Data are mean (95% confidence intervals). Results: A total of 1082 unique publications were identified; 1062 were excluded during screening. The remaining 20 studies with P∞ data were used to perform a meta-analysis. These included data from dog, rat, pig and human; 8 of these articles also provided data on MCFP. From this analysis P∞ = 26.5(23.4, 29.5) mmHg (n = 20) and the difference between P∞ and MCFP was 15.1(12.0, 18.3) mmHg (n = 8). Conclusions: P∞ and MCFP differ substantially, indicating non-equilibration of pressures in the circulation following cessation of flow at least in the short-term (seconds to minutes).https://www.atlantis-press.com/article/125930046/view |
| spellingShingle | Alun Hughes Kim Parker Ashraf Khir P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS Artery Research |
| title | P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS |
| title_full | P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS |
| title_fullStr | P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS |
| title_full_unstemmed | P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS |
| title_short | P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS |
| title_sort | p53 zero flow pressure pinfinity is larger than mean circulatory filling pressure a systematic review and meta analysis |
| url | https://www.atlantis-press.com/article/125930046/view |
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