Pharmacological and Immunological Aspects of Phage Therapy
Abstract. Bacteriophages, or viruses of microbes, when used as a medical strategy, might be able to solve the current crisis mankind faces with the increasing number of pathogens being antibiotic-resistant, where chemical drugs seized to show any therapeutic effect. The so-called phage therapy may b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2019-12-01
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| Series: | Infectious Microbes & Diseases |
| Online Access: | http://journals.lww.com/10.1097/IM9.0000000000000013 |
| _version_ | 1818742773503754240 |
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| author | Prasanth Manohar Ashok. J. Tamhankar Sebastian Leptihn Nachimuthu Ramesh Stijn van der Veen |
| author_facet | Prasanth Manohar Ashok. J. Tamhankar Sebastian Leptihn Nachimuthu Ramesh Stijn van der Veen |
| author_sort | Prasanth Manohar |
| collection | DOAJ |
| description | Abstract. Bacteriophages, or viruses of microbes, when used as a medical strategy, might be able to solve the current crisis mankind faces with the increasing number of pathogens being antibiotic-resistant, where chemical drugs seized to show any therapeutic effect. The so-called phage therapy may be one of the most promising alternatives to treat infections caused by antibiotic-resistant bacteria, which are killed after infection by a phage. While phages that destroy the host by lysis are chosen for therapy, many pharmacological and immunological aspects of phages as medicines have not been established so far. The immune system plays an important role in a process called phage acceptance where both, innate and adaptive immune responses of the host are involved. However, not only medical aspects but also social ones such as lacking public awareness or acceptance, and lack of structured regulatory guidelines are challenges that have to be addressed in the near future to establish phage therapy as a reliable and safe alternative for the treatment of infections. This review focuses on the unique pharmacological and immunological aspects of phages used in therapy. |
| first_indexed | 2024-12-18T02:17:51Z |
| format | Article |
| id | doaj.art-f6813009fe8a438e8aaa8c5c9a69b2bf |
| institution | Directory Open Access Journal |
| issn | 2641-5917 |
| language | English |
| last_indexed | 2024-12-18T02:17:51Z |
| publishDate | 2019-12-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Infectious Microbes & Diseases |
| spelling | doaj.art-f6813009fe8a438e8aaa8c5c9a69b2bf2022-12-21T21:24:21ZengWolters Kluwer HealthInfectious Microbes & Diseases2641-59172019-12-0112344210.1097/IM9.0000000000000013201912000-00002Pharmacological and Immunological Aspects of Phage TherapyPrasanth ManoharAshok. J. TamhankarSebastian LeptihnNachimuthu RameshStijn van der VeenAbstract. Bacteriophages, or viruses of microbes, when used as a medical strategy, might be able to solve the current crisis mankind faces with the increasing number of pathogens being antibiotic-resistant, where chemical drugs seized to show any therapeutic effect. The so-called phage therapy may be one of the most promising alternatives to treat infections caused by antibiotic-resistant bacteria, which are killed after infection by a phage. While phages that destroy the host by lysis are chosen for therapy, many pharmacological and immunological aspects of phages as medicines have not been established so far. The immune system plays an important role in a process called phage acceptance where both, innate and adaptive immune responses of the host are involved. However, not only medical aspects but also social ones such as lacking public awareness or acceptance, and lack of structured regulatory guidelines are challenges that have to be addressed in the near future to establish phage therapy as a reliable and safe alternative for the treatment of infections. This review focuses on the unique pharmacological and immunological aspects of phages used in therapy.http://journals.lww.com/10.1097/IM9.0000000000000013 |
| spellingShingle | Prasanth Manohar Ashok. J. Tamhankar Sebastian Leptihn Nachimuthu Ramesh Stijn van der Veen Pharmacological and Immunological Aspects of Phage Therapy Infectious Microbes & Diseases |
| title | Pharmacological and Immunological Aspects of Phage Therapy |
| title_full | Pharmacological and Immunological Aspects of Phage Therapy |
| title_fullStr | Pharmacological and Immunological Aspects of Phage Therapy |
| title_full_unstemmed | Pharmacological and Immunological Aspects of Phage Therapy |
| title_short | Pharmacological and Immunological Aspects of Phage Therapy |
| title_sort | pharmacological and immunological aspects of phage therapy |
| url | http://journals.lww.com/10.1097/IM9.0000000000000013 |
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