Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials
This systematic review and meta-analysis (PROSPERO registration; ref CRD 42020198921) aimed to govern photobiomodulation therapy (PBMT) efficacy in temporomandibular disorder (TMD). PRISMA guidelines and Cochrane Collaboration recommendations were followed. Differences in pain reduction assessment b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/7/1028 |
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| author | Reem Hanna Snehal Dalvi René Jean Bensadoun Stefano Benedicenti |
| author_facet | Reem Hanna Snehal Dalvi René Jean Bensadoun Stefano Benedicenti |
| author_sort | Reem Hanna |
| collection | DOAJ |
| description | This systematic review and meta-analysis (PROSPERO registration; ref CRD 42020198921) aimed to govern photobiomodulation therapy (PBMT) efficacy in temporomandibular disorder (TMD). PRISMA guidelines and Cochrane Collaboration recommendations were followed. Differences in pain reduction assessment by qualitative measurement with visual analogue scale (VAS), pain pressure threshold (PPT) and maximum mouth opening (MMO) were calculated with 95% confidence intervals and pooled in a random effects model with a subgroup analysis, evaluating the role of follow-up duration. Heterogeneity was analysed using Q and I<sup>2</sup> tests. Publication bias was assessed by visual examination of funnel plot symmetry. Qualitative analysis revealed 46% of the 44 included studies showed a high risk of bias. Meta-analysis on 32 out of 44 studies revealed statistically significant intergroup differences (SSID) for VAS (SMD = −0.55; 95% CI = −0.82 to −0.27; Z = 3.90 (<i>p</i> < 0.001)), PPT (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (<i>p</i> = 0.05)) and MMO (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (<i>p</i> = 0.05)), favouring PBMT compared to control treatment strategies. Sensitivity analysis revealed SSID (SMD = −0.53; 95% CI = −0.73 to −0.32; Z = 5.02 (<i>p</i> < 0.0001)) with low heterogeneity (Τ<sup>2</sup> = 0.02; χ<sup>2</sup> = 16.03 (<i>p</i> = 0.31); I<sup>2</sup> = 13%). Hence, this review, for first time, proposed suggested recommendations for PBMT protocols and methodology for future extensive TMD research. |
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| format | Article |
| id | doaj.art-f68183cf233c41299847bf3117f50f66 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T10:03:10Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-f68183cf233c41299847bf3117f50f662023-11-22T01:48:02ZengMDPI AGAntioxidants2076-39212021-06-01107102810.3390/antiox10071028Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled TrialsReem Hanna0Snehal Dalvi1René Jean Bensadoun2Stefano Benedicenti3Department of Surgical Sciences and Integrated Diagnostics, Laser Therapy Centre, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, ItalyDepartment of Periodontology, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur 441110, IndiaDepartment of Oncology Radiology, Centre De Haute Energie, 10 Boulevard Pasteur, 06000 Nice, FranceDepartment of Surgical Sciences and Integrated Diagnostics, Laser Therapy Centre, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, ItalyThis systematic review and meta-analysis (PROSPERO registration; ref CRD 42020198921) aimed to govern photobiomodulation therapy (PBMT) efficacy in temporomandibular disorder (TMD). PRISMA guidelines and Cochrane Collaboration recommendations were followed. Differences in pain reduction assessment by qualitative measurement with visual analogue scale (VAS), pain pressure threshold (PPT) and maximum mouth opening (MMO) were calculated with 95% confidence intervals and pooled in a random effects model with a subgroup analysis, evaluating the role of follow-up duration. Heterogeneity was analysed using Q and I<sup>2</sup> tests. Publication bias was assessed by visual examination of funnel plot symmetry. Qualitative analysis revealed 46% of the 44 included studies showed a high risk of bias. Meta-analysis on 32 out of 44 studies revealed statistically significant intergroup differences (SSID) for VAS (SMD = −0.55; 95% CI = −0.82 to −0.27; Z = 3.90 (<i>p</i> < 0.001)), PPT (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (<i>p</i> = 0.05)) and MMO (SMD = −0.45; 95% CI = −0.89 to 0.00; Z = 1.97 (<i>p</i> = 0.05)), favouring PBMT compared to control treatment strategies. Sensitivity analysis revealed SSID (SMD = −0.53; 95% CI = −0.73 to −0.32; Z = 5.02 (<i>p</i> < 0.0001)) with low heterogeneity (Τ<sup>2</sup> = 0.02; χ<sup>2</sup> = 16.03 (<i>p</i> = 0.31); I<sup>2</sup> = 13%). Hence, this review, for first time, proposed suggested recommendations for PBMT protocols and methodology for future extensive TMD research.https://www.mdpi.com/2076-3921/10/7/1028low-level laser therapyoxidative stressreactive oxygen speciestemporomandibular joint disorderrandomised controlled trialsphotobiomodulation |
| spellingShingle | Reem Hanna Snehal Dalvi René Jean Bensadoun Stefano Benedicenti Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials Antioxidants low-level laser therapy oxidative stress reactive oxygen species temporomandibular joint disorder randomised controlled trials photobiomodulation |
| title | Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials |
| title_full | Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials |
| title_fullStr | Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials |
| title_full_unstemmed | Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials |
| title_short | Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials |
| title_sort | role of photobiomodulation therapy in modulating oxidative stress in temporomandibular disorders a systematic review and meta analysis of human randomised controlled trials |
| topic | low-level laser therapy oxidative stress reactive oxygen species temporomandibular joint disorder randomised controlled trials photobiomodulation |
| url | https://www.mdpi.com/2076-3921/10/7/1028 |
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