Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations
Abstract Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. T...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-06-01
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| Series: | Insights into Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13244-021-01000-x |
| _version_ | 1819138801935581184 |
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| author | Pietro Valerio Foti Mario Travali Renato Farina Stefano Palmucci Corrado Spatola Luigi Raffaele Vincenzo Salamone Rosario Caltabiano Giuseppe Broggi Lidia Puzzo Andrea Russo Michele Reibaldi Antonio Longo Paolo Vigneri Teresio Avitabile Giovani Carlo Ettorre Antonio Basile |
| author_facet | Pietro Valerio Foti Mario Travali Renato Farina Stefano Palmucci Corrado Spatola Luigi Raffaele Vincenzo Salamone Rosario Caltabiano Giuseppe Broggi Lidia Puzzo Andrea Russo Michele Reibaldi Antonio Longo Paolo Vigneri Teresio Avitabile Giovani Carlo Ettorre Antonio Basile |
| author_sort | Pietro Valerio Foti |
| collection | DOAJ |
| description | Abstract Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagnosis is fundamentally based on clinical evaluation (ophthalmoscopy, biomicroscopy) and ultrasonography. MRI is useful in case of untransparent lens or subretinal effusion. Moreover, MRI has a significant role to confirm the diagnosis, in the evaluation of the local extent of the disease with implications for treatment planning, and in the follow-up after radiotherapy treatment. Uveal melanoma can show different morphologic features (lentiform, dome or mushroom shape) and often determines retinal detachment. MR appearance of uveal melanoma mainly depends on the melanin content. Uveal melanoma typically displays high signal intensity on T1-weighted images and low signal intensity on T2-weighted images. Nevertheless, imaging appearance may be variable based on the degree of pigmentation and the presence of areas of necrosis or cavitation. Differential diagnosis includes other uveal lesions. The radiologists and in particular MRI play a significant role in the clinical management of uveal melanoma. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present first section we summarize the MR anatomy of the eye and describe ophthalmological and radiological imaging techniques to diagnose uveal melanomas, with emphasis on the role of MR imaging. Additionally, we review MR imaging appearance of uveal melanomas. |
| first_indexed | 2024-12-22T11:12:33Z |
| format | Article |
| id | doaj.art-f6833020d96d4418b9a77f5732aa388d |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-12-22T11:12:33Z |
| publishDate | 2021-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-f6833020d96d4418b9a77f5732aa388d2022-12-21T18:28:08ZengSpringerOpenInsights into Imaging1869-41012021-06-0112112710.1186/s13244-021-01000-xDiagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerationsPietro Valerio Foti0Mario Travali1Renato Farina2Stefano Palmucci3Corrado Spatola4Luigi Raffaele5Vincenzo Salamone6Rosario Caltabiano7Giuseppe Broggi8Lidia Puzzo9Andrea Russo10Michele Reibaldi11Antonio Longo12Paolo Vigneri13Teresio Avitabile14Giovani Carlo Ettorre15Antonio Basile16Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Section of Anatomic Pathology, University of CataniaDepartment of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Section of Anatomic Pathology, University of CataniaDepartment of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Section of Anatomic Pathology, University of CataniaDepartment of Ophthalmology, University of CataniaDepartment of Ophthalmology, University of CataniaDepartment of Ophthalmology, University of CataniaDepartment of Clinical and Experimental Medicine, Center of Experimental Oncology and Hematology, University Hospital Policlinico “G. Rodolico-San Marco”Department of Ophthalmology, University of CataniaDepartment of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” – Radiology I Unit, University Hospital Policlinico “G. Rodolico-San Marco”Abstract Uveal melanoma is a malignant neoplasm that derives from pigmented melanocytes of the uvea and involves, in order of decreasing prevalence, the choroid, ciliary body and iris. Its prognosis is related to histopathologic and genetic features, tumor size and location, extraocular extension. The diagnosis is fundamentally based on clinical evaluation (ophthalmoscopy, biomicroscopy) and ultrasonography. MRI is useful in case of untransparent lens or subretinal effusion. Moreover, MRI has a significant role to confirm the diagnosis, in the evaluation of the local extent of the disease with implications for treatment planning, and in the follow-up after radiotherapy treatment. Uveal melanoma can show different morphologic features (lentiform, dome or mushroom shape) and often determines retinal detachment. MR appearance of uveal melanoma mainly depends on the melanin content. Uveal melanoma typically displays high signal intensity on T1-weighted images and low signal intensity on T2-weighted images. Nevertheless, imaging appearance may be variable based on the degree of pigmentation and the presence of areas of necrosis or cavitation. Differential diagnosis includes other uveal lesions. The radiologists and in particular MRI play a significant role in the clinical management of uveal melanoma. The purpose of this pictorial review is to provide the radiologists with awareness about diagnostic methods and therapeutic options of uveal melanoma. In the present first section we summarize the MR anatomy of the eye and describe ophthalmological and radiological imaging techniques to diagnose uveal melanomas, with emphasis on the role of MR imaging. Additionally, we review MR imaging appearance of uveal melanomas.https://doi.org/10.1186/s13244-021-01000-xMagnetic resonance imagingDiffusion magnetic resonance imagingMelanomaRetinal detachmentEye |
| spellingShingle | Pietro Valerio Foti Mario Travali Renato Farina Stefano Palmucci Corrado Spatola Luigi Raffaele Vincenzo Salamone Rosario Caltabiano Giuseppe Broggi Lidia Puzzo Andrea Russo Michele Reibaldi Antonio Longo Paolo Vigneri Teresio Avitabile Giovani Carlo Ettorre Antonio Basile Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations Insights into Imaging Magnetic resonance imaging Diffusion magnetic resonance imaging Melanoma Retinal detachment Eye |
| title | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
| title_full | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
| title_fullStr | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
| title_full_unstemmed | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
| title_short | Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging—Part I: MR imaging with pathologic correlation and technical considerations |
| title_sort | diagnostic methods and therapeutic options of uveal melanoma with emphasis on mr imaging part i mr imaging with pathologic correlation and technical considerations |
| topic | Magnetic resonance imaging Diffusion magnetic resonance imaging Melanoma Retinal detachment Eye |
| url | https://doi.org/10.1186/s13244-021-01000-x |
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