Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
Xu Jiang,1,* Yang Pan,1,* Sha Zhu,1 Yaxi Wang,1 Ruxin Gu,1 Yinyin Jiang,1 Bo Shen,1 Jun Zhu,1 Shulan Xu,1 Jun Yan,1 Jingde Dong,1 Wenbin Zhang,2 Chaoyong Xiao,3 Li Zhang1 1Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Rep...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/alterations-of-regional-homogeneity-in-parkinsons-disease-with-rapid-e-peer-reviewed-fulltext-article-NDT |
| _version_ | 1811196032616235008 |
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| author | Jiang X Pan Y Zhu S Wang Y Gu R Jiang Y Shen B Zhu J Xu S Yan J Dong J Zhang W Xiao C Zhang L |
| author_facet | Jiang X Pan Y Zhu S Wang Y Gu R Jiang Y Shen B Zhu J Xu S Yan J Dong J Zhang W Xiao C Zhang L |
| author_sort | Jiang X |
| collection | DOAJ |
| description | Xu Jiang,1,* Yang Pan,1,* Sha Zhu,1 Yaxi Wang,1 Ruxin Gu,1 Yinyin Jiang,1 Bo Shen,1 Jun Zhu,1 Shulan Xu,1 Jun Yan,1 Jingde Dong,1 Wenbin Zhang,2 Chaoyong Xiao,3 Li Zhang1 1Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Neurosurgery, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Radiology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zhang, Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China, Email jx13773958367@163.comObjective: Patients with rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson’s disease (PD-RBD) tend to have poor cognitive performance and faster cognitive deterioration, and the potential mechanism is still ambiguous. Therefore, this study aimed to detect the alterations in local brain function in PD-RBD.Methods: Fifty patients, including 23 patients with PD-RBD and 27 patients with PD without RBD (PD-nRBD), and 26 healthy controls were enrolled. All subjects were subjected to one-night polysomnography and underwent resting-state functional magnetic resonance imaging (rs-fMRI). The fMRI images of the three groups were analyzed by regional homogeneity (ReHo) to observe the local neural activity. Correlations between altered ReHo values and chin electromyographic (EMG) density scores and cognitive scores in the PD subgroups were assessed.Results: Compared with the patients with PD-nRBD, the patients with PD-RBD had higher ReHo values in the frontal cortex (the right superior frontal gyrus, the right middle frontal gyrus and the left medial superior frontal gyrus), the right caudate nucleus and the right anterior cingulate gyrus, and compared with the HCs, the patients with PD-RBD had lower ReHo values in the bilateral cuneus, the bilateral precuneus, the left inferior temporal gyrus and the left inferior occipital gyrus. For the patients with PD-RBD, the phasic chin EMG density scores were positively correlated with the ReHo values in the left medial superior frontal gyrus, and the tonic chin EMG density scores were positively correlated with the ReHo values in the right anterior cingulate gyrus.Conclusion: This study indicates that increased ReHo in the frontal cortex, the caudate nucleus and the anterior cingulate gyrus may be linked with the abnormal motor behaviors during REM sleep and that decreased ReHo in the posterior regions may be related to the visuospatial–executive function in patients with PD-RBD.Keywords: Parkinson’s disease, rapid eye movement sleep behavior disorder, resting-state fMRI, regional homogeneity |
| first_indexed | 2024-04-12T00:52:00Z |
| format | Article |
| id | doaj.art-f683c69ce1c0421e81c8c6399d07dcc7 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-04-12T00:52:00Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-f683c69ce1c0421e81c8c6399d07dcc72022-12-22T03:54:42ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212022-12-01Volume 182967297880445Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior DisorderJiang XPan YZhu SWang YGu RJiang YShen BZhu JXu SYan JDong JZhang WXiao CZhang LXu Jiang,1,* Yang Pan,1,* Sha Zhu,1 Yaxi Wang,1 Ruxin Gu,1 Yinyin Jiang,1 Bo Shen,1 Jun Zhu,1 Shulan Xu,1 Jun Yan,1 Jingde Dong,1 Wenbin Zhang,2 Chaoyong Xiao,3 Li Zhang1 1Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Neurosurgery, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Radiology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zhang, Department of Geriatrics, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China, Email jx13773958367@163.comObjective: Patients with rapid eye movement (REM) sleep behavior disorder (RBD) in Parkinson’s disease (PD-RBD) tend to have poor cognitive performance and faster cognitive deterioration, and the potential mechanism is still ambiguous. Therefore, this study aimed to detect the alterations in local brain function in PD-RBD.Methods: Fifty patients, including 23 patients with PD-RBD and 27 patients with PD without RBD (PD-nRBD), and 26 healthy controls were enrolled. All subjects were subjected to one-night polysomnography and underwent resting-state functional magnetic resonance imaging (rs-fMRI). The fMRI images of the three groups were analyzed by regional homogeneity (ReHo) to observe the local neural activity. Correlations between altered ReHo values and chin electromyographic (EMG) density scores and cognitive scores in the PD subgroups were assessed.Results: Compared with the patients with PD-nRBD, the patients with PD-RBD had higher ReHo values in the frontal cortex (the right superior frontal gyrus, the right middle frontal gyrus and the left medial superior frontal gyrus), the right caudate nucleus and the right anterior cingulate gyrus, and compared with the HCs, the patients with PD-RBD had lower ReHo values in the bilateral cuneus, the bilateral precuneus, the left inferior temporal gyrus and the left inferior occipital gyrus. For the patients with PD-RBD, the phasic chin EMG density scores were positively correlated with the ReHo values in the left medial superior frontal gyrus, and the tonic chin EMG density scores were positively correlated with the ReHo values in the right anterior cingulate gyrus.Conclusion: This study indicates that increased ReHo in the frontal cortex, the caudate nucleus and the anterior cingulate gyrus may be linked with the abnormal motor behaviors during REM sleep and that decreased ReHo in the posterior regions may be related to the visuospatial–executive function in patients with PD-RBD.Keywords: Parkinson’s disease, rapid eye movement sleep behavior disorder, resting-state fMRI, regional homogeneityhttps://www.dovepress.com/alterations-of-regional-homogeneity-in-parkinsons-disease-with-rapid-e-peer-reviewed-fulltext-article-NDTparkinson’s diseaserapid eye movement sleep behavior disorderresting-state fmriregional homogeneity |
| spellingShingle | Jiang X Pan Y Zhu S Wang Y Gu R Jiang Y Shen B Zhu J Xu S Yan J Dong J Zhang W Xiao C Zhang L Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder Neuropsychiatric Disease and Treatment parkinson’s disease rapid eye movement sleep behavior disorder resting-state fmri regional homogeneity |
| title | Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder |
| title_full | Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder |
| title_fullStr | Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder |
| title_full_unstemmed | Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder |
| title_short | Alterations of Regional Homogeneity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder |
| title_sort | alterations of regional homogeneity in parkinson rsquo s disease with rapid eye movement sleep behavior disorder |
| topic | parkinson’s disease rapid eye movement sleep behavior disorder resting-state fmri regional homogeneity |
| url | https://www.dovepress.com/alterations-of-regional-homogeneity-in-parkinsons-disease-with-rapid-e-peer-reviewed-fulltext-article-NDT |
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