TP53 Mutations Identified Using NGS Comprise the Overwhelming Majority of TP53 Disruptions in CLL: Results From a Multicentre Study

TP53 Mutations Identified Using NGS Comprise the Overwhelming Majority of TP53 Disruptions in CLL: Results From a Multicentre Study

Limited data exists to show the correlation of (tumour protein 53) TP53 mutation detected by Next generation sequencing (NGS) and the presence/absence of deletions of 17p13 detected by FISH. The study which is the largest series to date includes 2332 CLL patients referred for analysis of del(17p) by...

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Bibliographic Details
Main Authors: Mark A. Catherwood, Dorte Wren, Laura Chiecchio, Doriane Cavalieri, David Donaldson, Sarah Lawless, Ezzat ElHassadi, Amjad Hayat, Mary R. Cahill, Derville O’Shea, Jeremy Sargent, Peter Stewart, Manisha Maurya, John Quinn, Philip Murphy, David Gonzalez de Castro, Ken Mills, Nicholas C. P. Cross, Francesco Forconi, Sunil Iyengar, Anna Schuh, Patrick Thornton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukaemia
p53
deletion 17p
prognosis
next generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.909615/full

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