Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer

Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease that typically features a dramatic desmoplastic reaction, especially fibroblasts. The roles of cancer-associated fibroblasts (CAFs) in PDAC have received more attention in recent years. As increasing evidence suggests the heterogenei...

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Bibliographic Details
Main Authors: Xinglong Geng, Hongze Chen, Liang Zhao, Jisheng Hu, Wenbo Yang, Guanqun Li, Chundong Cheng, Zhongjie Zhao, Tao Zhang, Le Li, Bei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cancer-associated fibroblasts
heterogeneity
pancreatic cancer
hallmark
diagnosis
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.655152/full

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