The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia

The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia

Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are mutated in many human cancers. In this article, we make use of a Drosophila genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI/SNF complex proteins. Members of the BAP complex exhibit t...

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Bibliographic Details
Main Authors: Shilin Song, Héctor Herranz, Stephen M. Cohen
Format: Article
Language:English
Published: The Company of Biologists 2017-10-01
Series:Disease Models & Mechanisms
Subjects:
SWI/SNF
Hippo pathway
Yorkie
Oncogenic cooperation
Cancer
Drosophila
Online Access:http://dmm.biologists.org/content/10/10/1201

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