Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine
Epigenetic modifications play a fundamental role in the progression of coronary artery disease (CAD). This panoramic review aims to provide an overview of the current understanding of the epigenetic mechanisms involved in CAD pathogenesis and highlights the potential implications for personalized me...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/10/2864 |
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| author | Marcello Bergonzini Francesco Loreni Antonio Lio Marco Russo Guglielmo Saitto Antonio Cammardella Francesco Irace Corrado Tramontin Massimo Chello Mario Lusini Antonio Nenna Chiara Ferrisi Federico Ranocchi Francesco Musumeci |
| author_facet | Marcello Bergonzini Francesco Loreni Antonio Lio Marco Russo Guglielmo Saitto Antonio Cammardella Francesco Irace Corrado Tramontin Massimo Chello Mario Lusini Antonio Nenna Chiara Ferrisi Federico Ranocchi Francesco Musumeci |
| author_sort | Marcello Bergonzini |
| collection | DOAJ |
| description | Epigenetic modifications play a fundamental role in the progression of coronary artery disease (CAD). This panoramic review aims to provide an overview of the current understanding of the epigenetic mechanisms involved in CAD pathogenesis and highlights the potential implications for personalized medicine approaches. Epigenetics is the study of heritable changes that do not influence alterations in the DNA sequence of the genome. It has been shown that epigenetic processes, including DNA/histone methylation, acetylation, and phosphorylation, play an important role. Additionally, miRNAs, lncRNAs, and circRNAs are also involved in epigenetics, regulating gene expression patterns in response to various environmental factors and lifestyle choices. In the context of CAD, epigenetic alterations contribute to the dysregulation of genes involved in inflammation, oxidative stress, lipid metabolism, and vascular function. These epigenetic changes can occur during early developmental stages and persist throughout life, predisposing individuals to an increased risk of CAD. Furthermore, in recent years, the concept of personalized medicine has gained significant attention. Personalized medicine aims to tailor medical interventions based on an individual’s unique genetic, epigenetic, environmental, and lifestyle factors. In the context of CAD, understanding the interplay between genetic variants and epigenetic modifications holds promise for the development of more precise diagnostic tools, risk stratification models, and targeted therapies. This review summarizes the current knowledge of epigenetic mechanisms in CAD and discusses the fundamental principles of personalized medicine. |
| first_indexed | 2024-03-10T21:25:02Z |
| format | Article |
| id | doaj.art-f6880bd1fb05461db06614dcd7150c76 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T21:25:02Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f6880bd1fb05461db06614dcd7150c762023-11-19T15:48:13ZengMDPI AGBiomedicines2227-90592023-10-011110286410.3390/biomedicines11102864Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized MedicineMarcello Bergonzini0Francesco Loreni1Antonio Lio2Marco Russo3Guglielmo Saitto4Antonio Cammardella5Francesco Irace6Corrado Tramontin7Massimo Chello8Mario Lusini9Antonio Nenna10Chiara Ferrisi11Federico Ranocchi12Francesco Musumeci13Department of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyCardiac Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyCardiac Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyCardiac Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyCardiac Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyCardiac Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, 00152 Rome, ItalyEpigenetic modifications play a fundamental role in the progression of coronary artery disease (CAD). This panoramic review aims to provide an overview of the current understanding of the epigenetic mechanisms involved in CAD pathogenesis and highlights the potential implications for personalized medicine approaches. Epigenetics is the study of heritable changes that do not influence alterations in the DNA sequence of the genome. It has been shown that epigenetic processes, including DNA/histone methylation, acetylation, and phosphorylation, play an important role. Additionally, miRNAs, lncRNAs, and circRNAs are also involved in epigenetics, regulating gene expression patterns in response to various environmental factors and lifestyle choices. In the context of CAD, epigenetic alterations contribute to the dysregulation of genes involved in inflammation, oxidative stress, lipid metabolism, and vascular function. These epigenetic changes can occur during early developmental stages and persist throughout life, predisposing individuals to an increased risk of CAD. Furthermore, in recent years, the concept of personalized medicine has gained significant attention. Personalized medicine aims to tailor medical interventions based on an individual’s unique genetic, epigenetic, environmental, and lifestyle factors. In the context of CAD, understanding the interplay between genetic variants and epigenetic modifications holds promise for the development of more precise diagnostic tools, risk stratification models, and targeted therapies. This review summarizes the current knowledge of epigenetic mechanisms in CAD and discusses the fundamental principles of personalized medicine.https://www.mdpi.com/2227-9059/11/10/2864cardiovascular diseasesclinical epigeneticsbiomarkersdrug targetsDNA methylationhistone modification |
| spellingShingle | Marcello Bergonzini Francesco Loreni Antonio Lio Marco Russo Guglielmo Saitto Antonio Cammardella Francesco Irace Corrado Tramontin Massimo Chello Mario Lusini Antonio Nenna Chiara Ferrisi Federico Ranocchi Francesco Musumeci Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine Biomedicines cardiovascular diseases clinical epigenetics biomarkers drug targets DNA methylation histone modification |
| title | Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine |
| title_full | Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine |
| title_fullStr | Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine |
| title_full_unstemmed | Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine |
| title_short | Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine |
| title_sort | panoramic on epigenetics in coronary artery disease and the approach of personalized medicine |
| topic | cardiovascular diseases clinical epigenetics biomarkers drug targets DNA methylation histone modification |
| url | https://www.mdpi.com/2227-9059/11/10/2864 |
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