A ferret brain slice model of oxygen–glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes

A ferret brain slice model of oxygen–glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes

Abstract Organotypic brain slice models are an ideal technological platform to investigate therapeutic options for hypoxic‐ischemic (HI) brain injury, a leading cause of morbidity and mortality in neonates. The brain exhibits regional differences in the response to HI injury in vivo. This can be mod...

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Bibliographic Details
Main Authors: Thomas R. Wood, Kate Hildahl, Hawley Helmbrecht, Kylie A. Corry, Daniel H. Moralejo, Sarah E. Kolnik, Katherine E. Prater, Sandra E. Juul, Elizabeth Nance
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Bioengineering & Translational Medicine
Subjects:
ferret
machine learning
microglia
neonatal
neuroprotection
organotypic brain slice
Online Access:https://doi.org/10.1002/btm2.10265

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