Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New Classification
This study consists of a retrospective cohort study, a systematic review, and a meta-analysis which were separately conducted. This study aimed to investigate the prevalence of atlas arch defects, generate an evidence-based synthesis, and propose a common classification system for the anterior and c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Spine Society
2023-10-01
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| Series: | Asian Spine Journal |
| Subjects: | |
| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-2023-0030.pdf |
| _version_ | 1797644523623415808 |
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| author | Worawit Suphamungmee Laphatrada Yurasakpong Kanchanaphan Poonudom R. Shane Tubbs Joe Iwanaga Nutmethee Kruepunga Arada Chaiyamoon Athikhun Suwannakhan |
| author_facet | Worawit Suphamungmee Laphatrada Yurasakpong Kanchanaphan Poonudom R. Shane Tubbs Joe Iwanaga Nutmethee Kruepunga Arada Chaiyamoon Athikhun Suwannakhan |
| author_sort | Worawit Suphamungmee |
| collection | DOAJ |
| description | This study consists of a retrospective cohort study, a systematic review, and a meta-analysis which were separately conducted. This study aimed to investigate the prevalence of atlas arch defects, generate an evidence-based synthesis, and propose a common classification system for the anterior and combined atlas arch defects. Atlas arch defects are well-corticated gaps in the anterior or posterior arch of the atlas. When both arches are involved, it is known as a combined arch defect. Awareness of these defects is essential for avoiding complications during surgical procedures on the upper spine. The prevalence of arch defects was investigated in an open-access OPC-Radiomics (Radiomic Biomarkers in Oropharyngeal Carcinoma) dataset comprising 606 head and neck computed tomography scans from oropharyngeal cancer patients. A systematic review and meta-analysis were performed to generate prevalence estimates of atlas arch defects and propose a classification system for the anterior and combined atlas arch defects. The posterior arch defect was found in 20 patients (3.3%) out of the 606 patients investigated. The anterior arch defect was not observed in any patient, while a combined arch defect was observed in one patient (0.2%). A meta-analysis of 13,539 participants from 14 studies, including the present study, yielded a pooled-posterior arch defect prevalence of 2.07% (95% confidence interval [CI], 1.22%–2.92%). The prevalences of anterior and combined arch defects were 0.00% (95% CI, 0.00%–0.10%) and 0.14% (95% CI, 0.04%–0.25%), respectively. The anterior and combined arch defects were classified into five subtypes based on their morphology and frequency. The present study showed that atlas arch defects were present in approximately 2% of the general population. For future studies, larger sample sizes should be used for studying arch defects to avoid the small-study effect and to predict the prevalence accurately. |
| first_indexed | 2024-03-11T14:31:45Z |
| format | Article |
| id | doaj.art-f68d598319c045179a4c3aa2abf88c7e |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-03-11T14:31:45Z |
| publishDate | 2023-10-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-f68d598319c045179a4c3aa2abf88c7e2023-10-31T08:19:30ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462023-10-0117597598410.31616/asj.2023.00301557Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New ClassificationWorawit Suphamungmee0Laphatrada Yurasakpong1Kanchanaphan Poonudom2R. Shane Tubbs3Joe Iwanaga4Nutmethee Kruepunga5Arada Chaiyamoon6Athikhun Suwannakhan7 Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, Thailand Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, ThailandThis study consists of a retrospective cohort study, a systematic review, and a meta-analysis which were separately conducted. This study aimed to investigate the prevalence of atlas arch defects, generate an evidence-based synthesis, and propose a common classification system for the anterior and combined atlas arch defects. Atlas arch defects are well-corticated gaps in the anterior or posterior arch of the atlas. When both arches are involved, it is known as a combined arch defect. Awareness of these defects is essential for avoiding complications during surgical procedures on the upper spine. The prevalence of arch defects was investigated in an open-access OPC-Radiomics (Radiomic Biomarkers in Oropharyngeal Carcinoma) dataset comprising 606 head and neck computed tomography scans from oropharyngeal cancer patients. A systematic review and meta-analysis were performed to generate prevalence estimates of atlas arch defects and propose a classification system for the anterior and combined atlas arch defects. The posterior arch defect was found in 20 patients (3.3%) out of the 606 patients investigated. The anterior arch defect was not observed in any patient, while a combined arch defect was observed in one patient (0.2%). A meta-analysis of 13,539 participants from 14 studies, including the present study, yielded a pooled-posterior arch defect prevalence of 2.07% (95% confidence interval [CI], 1.22%–2.92%). The prevalences of anterior and combined arch defects were 0.00% (95% CI, 0.00%–0.10%) and 0.14% (95% CI, 0.04%–0.25%), respectively. The anterior and combined arch defects were classified into five subtypes based on their morphology and frequency. The present study showed that atlas arch defects were present in approximately 2% of the general population. For future studies, larger sample sizes should be used for studying arch defects to avoid the small-study effect and to predict the prevalence accurately.http://www.asianspinejournal.org/upload/pdf/asj-2023-0030.pdfcervical atlascomputed tomographysystematic reviewmeta-analysis |
| spellingShingle | Worawit Suphamungmee Laphatrada Yurasakpong Kanchanaphan Poonudom R. Shane Tubbs Joe Iwanaga Nutmethee Kruepunga Arada Chaiyamoon Athikhun Suwannakhan Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New Classification Asian Spine Journal cervical atlas computed tomography systematic review meta-analysis |
| title | Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New Classification |
| title_full | Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New Classification |
| title_fullStr | Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New Classification |
| title_full_unstemmed | Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New Classification |
| title_short | Radiological Study of Atlas Arch Defects with Meta-Analysis and a Proposed New Classification |
| title_sort | radiological study of atlas arch defects with meta analysis and a proposed new classification |
| topic | cervical atlas computed tomography systematic review meta-analysis |
| url | http://www.asianspinejournal.org/upload/pdf/asj-2023-0030.pdf |
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