Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases
Some antimicrobial peptides (AMPs) are produced in the vaginal innate immune system and play an important role in protecting this organ against pathogenic agents. Moreover, sexually transmitted diseases have become a major problem in human societies and are rapidly spreading. The emergence of antibi...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | New Microbes and New Infections |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2052297519301246 |
| _version_ | 1819047337708748800 |
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| author | H. Madanchi M. Shoushtari H.H. Kashani S. Sardari |
| author_facet | H. Madanchi M. Shoushtari H.H. Kashani S. Sardari |
| author_sort | H. Madanchi |
| collection | DOAJ |
| description | Some antimicrobial peptides (AMPs) are produced in the vaginal innate immune system and play an important role in protecting this organ against pathogenic agents. Moreover, sexually transmitted diseases have become a major problem in human societies and are rapidly spreading. The emergence of antibiotic-resistant microbes (superbugs) can pose a major threat to human societies and cause rapid spread of these diseases. Finding new antimicrobial compounds to fight superbugs is therefore essential. It has been shown that AMPs have good potential to become new antibiotics. The most important AMPs in the vaginal innate immune system are defensins, secretory leucocyte protease inhibitors, calprotectin, lysozyme, lactoferrin and elafin, which play an important role in host defence against sexually transmitted infections, modulation of immune responses and anticancer activities. Some AMPs, such as LL-37, magainin 2 and nisin, show both spermicidal and antimicrobial effects in the vagina. In this summary, we will discuss vaginal AMPs and continue to address some of the challenges of using peptides to control pathogens that are effective in sexually transmitted diseases. Keywords: Antimicrobial peptide, defensin, LL-37, sexually transmitted diseases, spermicidal peptides, vaginal innate immune system |
| first_indexed | 2024-12-21T10:58:46Z |
| format | Article |
| id | doaj.art-f690ec2f79fd4d2caba5e3db8852e728 |
| institution | Directory Open Access Journal |
| issn | 2052-2975 |
| language | English |
| last_indexed | 2024-12-21T10:58:46Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj.art-f690ec2f79fd4d2caba5e3db8852e7282022-12-21T19:06:26ZengElsevierNew Microbes and New Infections2052-29752020-03-0134Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseasesH. Madanchi0M. Shoushtari1H.H. Kashani2S. Sardari3Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran; Drug Design and Bioinformatics Unit, Department of Biotechnology Research Centre, Pasteur Institute of Iran, Tehran, IranDepartment of Virology, Pasteur Institute of Iran, Tehran, Iran; Corresponding author: M. Shoushtari, Department of Virology, Pasteur Institute of Iran, Tehran, Iran.Gametogenesis Research Centre, Kashan University of Medical Sciences, Kashan, Iran; Anatomical Sciences Research Centre, Basic Sciences Research Institute, Kashan University of Medical Sciences, Kashan, Iran; Corresponding author: H. Haddad Kashani, Anatomical Sciences Research Center, Basic Sciences Research Institute, Kashan University of Medical Sciences, Kashan, IranDrug Design and Bioinformatics Unit, Department of Biotechnology Research Centre, Pasteur Institute of Iran, Tehran, Iran; Corresponding author: S. Sardari, Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Centre, Pasteur Institute of Iran, Tehran, Iran.Some antimicrobial peptides (AMPs) are produced in the vaginal innate immune system and play an important role in protecting this organ against pathogenic agents. Moreover, sexually transmitted diseases have become a major problem in human societies and are rapidly spreading. The emergence of antibiotic-resistant microbes (superbugs) can pose a major threat to human societies and cause rapid spread of these diseases. Finding new antimicrobial compounds to fight superbugs is therefore essential. It has been shown that AMPs have good potential to become new antibiotics. The most important AMPs in the vaginal innate immune system are defensins, secretory leucocyte protease inhibitors, calprotectin, lysozyme, lactoferrin and elafin, which play an important role in host defence against sexually transmitted infections, modulation of immune responses and anticancer activities. Some AMPs, such as LL-37, magainin 2 and nisin, show both spermicidal and antimicrobial effects in the vagina. In this summary, we will discuss vaginal AMPs and continue to address some of the challenges of using peptides to control pathogens that are effective in sexually transmitted diseases. Keywords: Antimicrobial peptide, defensin, LL-37, sexually transmitted diseases, spermicidal peptides, vaginal innate immune systemhttp://www.sciencedirect.com/science/article/pii/S2052297519301246 |
| spellingShingle | H. Madanchi M. Shoushtari H.H. Kashani S. Sardari Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases New Microbes and New Infections |
| title | Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases |
| title_full | Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases |
| title_fullStr | Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases |
| title_full_unstemmed | Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases |
| title_short | Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases |
| title_sort | antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2052297519301246 |
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