Hemodynamic traveling waves in human visual cortex.
Functional MRI (fMRI) experiments rely on precise characterization of the blood oxygen level dependent (BOLD) signal. As the spatial resolution of fMRI reaches the sub-millimeter range, the need for quantitative modelling of spatiotemporal properties of this hemodynamic signal has become pressing. H...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC3310706?pdf=render |
| _version_ | 1830406849842642944 |
|---|---|
| author | Kevin M Aquino Mark M Schira P A Robinson Peter M Drysdale Michael Breakspear |
| author_facet | Kevin M Aquino Mark M Schira P A Robinson Peter M Drysdale Michael Breakspear |
| author_sort | Kevin M Aquino |
| collection | DOAJ |
| description | Functional MRI (fMRI) experiments rely on precise characterization of the blood oxygen level dependent (BOLD) signal. As the spatial resolution of fMRI reaches the sub-millimeter range, the need for quantitative modelling of spatiotemporal properties of this hemodynamic signal has become pressing. Here, we find that a detailed physiologically-based model of spatiotemporal BOLD responses predicts traveling waves with velocities and spatial ranges in empirically observable ranges. Two measurable parameters, related to physiology, characterize these waves: wave velocity and damping rate. To test these predictions, high-resolution fMRI data are acquired from subjects viewing discrete visual stimuli. Predictions and experiment show strong agreement, in particular confirming BOLD waves propagating for at least 5-10 mm across the cortical surface at speeds of 2-12 mm s-1. These observations enable fundamentally new approaches to fMRI analysis, crucial for fMRI data acquired at high spatial resolution. |
| first_indexed | 2024-12-20T18:18:20Z |
| format | Article |
| id | doaj.art-f691cc70a4544a66b113d1dafa2cb4ad |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-20T18:18:20Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-f691cc70a4544a66b113d1dafa2cb4ad2022-12-21T19:30:20ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582012-01-0183e100243510.1371/journal.pcbi.1002435Hemodynamic traveling waves in human visual cortex.Kevin M AquinoMark M SchiraP A RobinsonPeter M DrysdaleMichael BreakspearFunctional MRI (fMRI) experiments rely on precise characterization of the blood oxygen level dependent (BOLD) signal. As the spatial resolution of fMRI reaches the sub-millimeter range, the need for quantitative modelling of spatiotemporal properties of this hemodynamic signal has become pressing. Here, we find that a detailed physiologically-based model of spatiotemporal BOLD responses predicts traveling waves with velocities and spatial ranges in empirically observable ranges. Two measurable parameters, related to physiology, characterize these waves: wave velocity and damping rate. To test these predictions, high-resolution fMRI data are acquired from subjects viewing discrete visual stimuli. Predictions and experiment show strong agreement, in particular confirming BOLD waves propagating for at least 5-10 mm across the cortical surface at speeds of 2-12 mm s-1. These observations enable fundamentally new approaches to fMRI analysis, crucial for fMRI data acquired at high spatial resolution.http://europepmc.org/articles/PMC3310706?pdf=render |
| spellingShingle | Kevin M Aquino Mark M Schira P A Robinson Peter M Drysdale Michael Breakspear Hemodynamic traveling waves in human visual cortex. PLoS Computational Biology |
| title | Hemodynamic traveling waves in human visual cortex. |
| title_full | Hemodynamic traveling waves in human visual cortex. |
| title_fullStr | Hemodynamic traveling waves in human visual cortex. |
| title_full_unstemmed | Hemodynamic traveling waves in human visual cortex. |
| title_short | Hemodynamic traveling waves in human visual cortex. |
| title_sort | hemodynamic traveling waves in human visual cortex |
| url | http://europepmc.org/articles/PMC3310706?pdf=render |
| work_keys_str_mv | AT kevinmaquino hemodynamictravelingwavesinhumanvisualcortex AT markmschira hemodynamictravelingwavesinhumanvisualcortex AT parobinson hemodynamictravelingwavesinhumanvisualcortex AT petermdrysdale hemodynamictravelingwavesinhumanvisualcortex AT michaelbreakspear hemodynamictravelingwavesinhumanvisualcortex |