Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case Report
The present case report features a highly uncommon form of a paediatric TCF3-HLF positive acute lymphoblastic leukaemia (ALL) relapse, an extramedullary, peripheral bone manifestation. Following complete remission, during the conditioning for haematopoietic stem cell transplantation (HSCT), our sixt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/12/1919 |
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| author | Máté Horváth Gabriella Kertész Csaba Kassa Vera Goda Kata Csordás Lidia Hau Anna Kövér Anita Stréhn Orsolya Horváth Krisztián Kállay Gergely Kriván |
| author_facet | Máté Horváth Gabriella Kertész Csaba Kassa Vera Goda Kata Csordás Lidia Hau Anna Kövér Anita Stréhn Orsolya Horváth Krisztián Kállay Gergely Kriván |
| author_sort | Máté Horváth |
| collection | DOAJ |
| description | The present case report features a highly uncommon form of a paediatric TCF3-HLF positive acute lymphoblastic leukaemia (ALL) relapse, an extramedullary, peripheral bone manifestation. Following complete remission, during the conditioning for haematopoietic stem cell transplantation (HSCT), our sixteen-year-old male patient complained of fever, pain and swelling of the right forearm. Radiography suggested acute osteomyelitis in the right ulna with subsequent surgical confirmation. Intraoperatively obtained debris culture grew <i>Staphylococcus aureus</i> and <i>Acinetobacter pittii</i>. Measures taken to control the infection were deemed to be successful. However, after the completion of the otherwise uneventful HSCT, a very early medullary relapse was diagnosed. Revising the original surgical samples from the ulna, bone relapse of ALL was immunohistochemically confirmed. Reviewing the previous cases found in the literature, it is advised to consider uncommon forms of ALL relapse when encountering ambiguous cases of osteomyelitis or arthritis during haematological remission. |
| first_indexed | 2024-03-09T17:11:56Z |
| format | Article |
| id | doaj.art-f691dd16b75a477ebe586e09e6971469 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T17:11:56Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-f691dd16b75a477ebe586e09e69714692023-11-24T14:02:00ZengMDPI AGChildren2227-90672022-12-01912191910.3390/children9121919Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case ReportMáté Horváth0Gabriella Kertész1Csaba Kassa2Vera Goda3Kata Csordás4Lidia Hau5Anna Kövér6Anita Stréhn7Orsolya Horváth8Krisztián Kállay9Gergely Kriván10Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryPediatric Hematology and Stem Cell Transplantation Unit, Central Hospital of Southern Pest National Institute of Hematology and Infectious Diseases, Albert Flórián Street 5-7, H-1097 Budapest, HungaryThe present case report features a highly uncommon form of a paediatric TCF3-HLF positive acute lymphoblastic leukaemia (ALL) relapse, an extramedullary, peripheral bone manifestation. Following complete remission, during the conditioning for haematopoietic stem cell transplantation (HSCT), our sixteen-year-old male patient complained of fever, pain and swelling of the right forearm. Radiography suggested acute osteomyelitis in the right ulna with subsequent surgical confirmation. Intraoperatively obtained debris culture grew <i>Staphylococcus aureus</i> and <i>Acinetobacter pittii</i>. Measures taken to control the infection were deemed to be successful. However, after the completion of the otherwise uneventful HSCT, a very early medullary relapse was diagnosed. Revising the original surgical samples from the ulna, bone relapse of ALL was immunohistochemically confirmed. Reviewing the previous cases found in the literature, it is advised to consider uncommon forms of ALL relapse when encountering ambiguous cases of osteomyelitis or arthritis during haematological remission.https://www.mdpi.com/2227-9067/9/12/1919acute lymphoblastic leukaemiahaematopoietic stem cell transplantationosteomyelitisrelapseextramedullary relapsebone relapse |
| spellingShingle | Máté Horváth Gabriella Kertész Csaba Kassa Vera Goda Kata Csordás Lidia Hau Anna Kövér Anita Stréhn Orsolya Horváth Krisztián Kállay Gergely Kriván Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case Report Children acute lymphoblastic leukaemia haematopoietic stem cell transplantation osteomyelitis relapse extramedullary relapse bone relapse |
| title | Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case Report |
| title_full | Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case Report |
| title_fullStr | Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case Report |
| title_full_unstemmed | Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case Report |
| title_short | Peripheral Bone Relapse of Paediatric TCF3-HLF Positive Acute Lymphoblastic Leukaemia during Haematopoietic Stem Cell Transplantation: A Case Report |
| title_sort | peripheral bone relapse of paediatric tcf3 hlf positive acute lymphoblastic leukaemia during haematopoietic stem cell transplantation a case report |
| topic | acute lymphoblastic leukaemia haematopoietic stem cell transplantation osteomyelitis relapse extramedullary relapse bone relapse |
| url | https://www.mdpi.com/2227-9067/9/12/1919 |
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