Glial Tiling in the Insect Nervous System
The Drosophila nervous system comprises a small number of well characterized glial cell classes. The outer surface of the central nervous system (CNS) is protected by a glial derived blood-brain barrier generated by perineurial and subperineurial glia. All neural stem cells and all neurons are engul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.825695/full |
| _version_ | 1819278147348070400 |
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| author | Nicole Pogodalla Bente Winkler Christian Klämbt |
| author_facet | Nicole Pogodalla Bente Winkler Christian Klämbt |
| author_sort | Nicole Pogodalla |
| collection | DOAJ |
| description | The Drosophila nervous system comprises a small number of well characterized glial cell classes. The outer surface of the central nervous system (CNS) is protected by a glial derived blood-brain barrier generated by perineurial and subperineurial glia. All neural stem cells and all neurons are engulfed by cortex glial cells. The inner neuropil region, that harbors all synapses and dendrites, is covered by ensheathing glia and infiltrated by astrocyte-like glial cells. All these glial cells show a tiled organization with an often remarkable plasticity where glial cells of one cell type invade the territory of the neighboring glial cell type upon its ablation. Here, we summarize the different glial tiling patterns and based on the different modes of cell-cell contacts we hypothesize that different molecular mechanisms underlie tiling of the different glial cell types. |
| first_indexed | 2024-12-24T00:07:23Z |
| format | Article |
| id | doaj.art-f692871504cc4f279e3b7f14f8da7a32 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-24T00:07:23Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-f692871504cc4f279e3b7f14f8da7a322022-12-21T17:24:58ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-02-011610.3389/fncel.2022.825695825695Glial Tiling in the Insect Nervous SystemNicole PogodallaBente WinklerChristian KlämbtThe Drosophila nervous system comprises a small number of well characterized glial cell classes. The outer surface of the central nervous system (CNS) is protected by a glial derived blood-brain barrier generated by perineurial and subperineurial glia. All neural stem cells and all neurons are engulfed by cortex glial cells. The inner neuropil region, that harbors all synapses and dendrites, is covered by ensheathing glia and infiltrated by astrocyte-like glial cells. All these glial cells show a tiled organization with an often remarkable plasticity where glial cells of one cell type invade the territory of the neighboring glial cell type upon its ablation. Here, we summarize the different glial tiling patterns and based on the different modes of cell-cell contacts we hypothesize that different molecular mechanisms underlie tiling of the different glial cell types.https://www.frontiersin.org/articles/10.3389/fncel.2022.825695/fulltilinggliaDrosophilacentral nervous systemcell-cell contacts |
| spellingShingle | Nicole Pogodalla Bente Winkler Christian Klämbt Glial Tiling in the Insect Nervous System Frontiers in Cellular Neuroscience tiling glia Drosophila central nervous system cell-cell contacts |
| title | Glial Tiling in the Insect Nervous System |
| title_full | Glial Tiling in the Insect Nervous System |
| title_fullStr | Glial Tiling in the Insect Nervous System |
| title_full_unstemmed | Glial Tiling in the Insect Nervous System |
| title_short | Glial Tiling in the Insect Nervous System |
| title_sort | glial tiling in the insect nervous system |
| topic | tiling glia Drosophila central nervous system cell-cell contacts |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.825695/full |
| work_keys_str_mv | AT nicolepogodalla glialtilingintheinsectnervoussystem AT bentewinkler glialtilingintheinsectnervoussystem AT christianklambt glialtilingintheinsectnervoussystem |