Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India
Abstract We aimed to evaluate the predictive accuracy of InsuTAG index against M value of the hyperinsulinaemic-Euglycaemic clamp (HEC) procedure and fasting surrogate indices of insulin sensitivity/resistance in young, normoglycaemic, Asian Indian males. HEC studies were done in young (mean age 19....
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| Format: | Article |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-45880-z |
| _version_ | 1797630278368231424 |
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| author | Felix K. Jebasingh Shajith Anoop Riddhi Dasgupta Mathews Edatharayil Kurian Aneez Joseph Grace Rebekah Venkataraghava Mohan Nihal Thomas |
| author_facet | Felix K. Jebasingh Shajith Anoop Riddhi Dasgupta Mathews Edatharayil Kurian Aneez Joseph Grace Rebekah Venkataraghava Mohan Nihal Thomas |
| author_sort | Felix K. Jebasingh |
| collection | DOAJ |
| description | Abstract We aimed to evaluate the predictive accuracy of InsuTAG index against M value of the hyperinsulinaemic-Euglycaemic clamp (HEC) procedure and fasting surrogate indices of insulin sensitivity/resistance in young, normoglycaemic, Asian Indian males. HEC studies were done in young (mean age 19.7 ± 1 years), non-obese (mean BMI 19.2 ± 2.6 kg/m2), normoglycemic Asian Indian males (n = 110) and the M value was calculated. Surrogate indices namely InsuTAG index, HOMA-IR, FG-IR, QUICKI and McAuley index were calculated. Pearson’s correlation and ROC-AUC at 95% CI were applied. Significant negative correlation was observed for InsuTAG index with the M value (r − 0.23, p = 0.01), McAuley index (r − 0.65, p < 0.01), QUICKI (r − 0.34, p < 0.01) and FGIR (r − 0.35, p < 0.01). Significant positive correlations of InsuTAG index were observed for BMI and waist circumference. The ROC-AUC was higher for InsuTAG index (0.75) than FGIR (0.30), QUICKI (0.31), and McAuley index (0.20). The InsuTAG cut-off value ≥ 19.13 showed 66.7% sensitivity and 69.2% specificity in this study group. |
| first_indexed | 2024-03-11T11:04:53Z |
| format | Article |
| id | doaj.art-f692f46ed6fe48c891298f22969f9670 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:04:53Z |
| publishDate | 2023-11-01 |
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| series | Scientific Reports |
| spelling | doaj.art-f692f46ed6fe48c891298f22969f96702023-11-12T12:17:29ZengNature PortfolioScientific Reports2045-23222023-11-011311810.1038/s41598-023-45880-zUnderstanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern IndiaFelix K. Jebasingh0Shajith Anoop1Riddhi Dasgupta2Mathews Edatharayil Kurian3Aneez Joseph4Grace Rebekah5Venkataraghava Mohan6Nihal Thomas7Department of Endocrinology, Diabetes and Metabolism, Christian Medical College VelloreDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College VelloreDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College VelloreDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College VelloreDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College VelloreDepartment of Biostatistics, Christian Medical CollegeDepartment of Community Health and Development, Christian Medical CollegeDepartment of Endocrinology, Diabetes and Metabolism, Christian Medical College VelloreAbstract We aimed to evaluate the predictive accuracy of InsuTAG index against M value of the hyperinsulinaemic-Euglycaemic clamp (HEC) procedure and fasting surrogate indices of insulin sensitivity/resistance in young, normoglycaemic, Asian Indian males. HEC studies were done in young (mean age 19.7 ± 1 years), non-obese (mean BMI 19.2 ± 2.6 kg/m2), normoglycemic Asian Indian males (n = 110) and the M value was calculated. Surrogate indices namely InsuTAG index, HOMA-IR, FG-IR, QUICKI and McAuley index were calculated. Pearson’s correlation and ROC-AUC at 95% CI were applied. Significant negative correlation was observed for InsuTAG index with the M value (r − 0.23, p = 0.01), McAuley index (r − 0.65, p < 0.01), QUICKI (r − 0.34, p < 0.01) and FGIR (r − 0.35, p < 0.01). Significant positive correlations of InsuTAG index were observed for BMI and waist circumference. The ROC-AUC was higher for InsuTAG index (0.75) than FGIR (0.30), QUICKI (0.31), and McAuley index (0.20). The InsuTAG cut-off value ≥ 19.13 showed 66.7% sensitivity and 69.2% specificity in this study group.https://doi.org/10.1038/s41598-023-45880-z |
| spellingShingle | Felix K. Jebasingh Shajith Anoop Riddhi Dasgupta Mathews Edatharayil Kurian Aneez Joseph Grace Rebekah Venkataraghava Mohan Nihal Thomas Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India Scientific Reports |
| title | Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India |
| title_full | Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India |
| title_fullStr | Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India |
| title_full_unstemmed | Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India |
| title_short | Understanding the predictive accuracy of the InsuTAG index over other surrogate indices in normoglycaemic, non-obese males from Southern India |
| title_sort | understanding the predictive accuracy of the insutag index over other surrogate indices in normoglycaemic non obese males from southern india |
| url | https://doi.org/10.1038/s41598-023-45880-z |
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