Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status
Schizophrenia (SCZ) is a profound neurological disorder that affects approximately 1% of the global population. Alpha-pinene (α-pinene) is a natural and active monoterpene found in coniferous tree oil, primarily pine, with diverse pharmacological characteristics, including antioxidative, anxiolytic,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242123022984 |
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| author | Akbar Hajizadeh Moghaddam Fatemeh Malekzadeh Estalkhi Sedigheh Khanjani Jelodar Tabarek Ahmed Hasan Soroush Farhadi-Pahnedari Mohammad Karimian |
| author_facet | Akbar Hajizadeh Moghaddam Fatemeh Malekzadeh Estalkhi Sedigheh Khanjani Jelodar Tabarek Ahmed Hasan Soroush Farhadi-Pahnedari Mohammad Karimian |
| author_sort | Akbar Hajizadeh Moghaddam |
| collection | DOAJ |
| description | Schizophrenia (SCZ) is a profound neurological disorder that affects approximately 1% of the global population. Alpha-pinene (α-pinene) is a natural and active monoterpene found in coniferous tree oil, primarily pine, with diverse pharmacological characteristics, including antioxidative, anxiolytic, and antidepressant properties. This research study delves into the neuroprotective effects of α-pinene on oxidative stress, memory deficits, and depressive and anxiety-like behaviors in a ketamine-induced mice model of SCZ using male mice. The mice were randomly divided into six groups: vehicle, control, positive control, ketamine, α-pinene at 50 mg/kg, and α-pinene at 100 mg/kg. Treatment of the ketamine-induced mice model of SCZ with α-pinene yielded significant improvements in depressive and anxiety-like behaviors and cognitive impairments. Furthermore, it significantly elevated glutathione (GSH) levels, total antioxidant capacity (TAC), dopamine levels, catalase (CAT), and superoxide dismutase (SOD) activities while markedly reducing malondialdehyde (MDA) levels. The current study establishes that α-pinene treatment effectively mitigates oxidative damage, cognitive deficits, and depressive and anxiogenic-like behaviors in the brains of ketamine-treated mice. Therefore, α-pinene treatment is an efficacious approach to forestall the neurobehavioral and neurobiochemical adverse effects of the ketamine-induced SCZ model of mice. |
| first_indexed | 2024-03-08T10:15:12Z |
| format | Article |
| id | doaj.art-f6944e1dfeab4ed1bb3d3d7e8e6de57e |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-03-08T10:15:12Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-f6944e1dfeab4ed1bb3d3d7e8e6de57e2024-01-29T04:16:40ZengElsevierIBRO Neuroscience Reports2667-24212024-06-0116182189Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress statusAkbar Hajizadeh Moghaddam0Fatemeh Malekzadeh Estalkhi1Sedigheh Khanjani Jelodar2Tabarek Ahmed Hasan3Soroush Farhadi-Pahnedari4Mohammad Karimian5Department of Animal Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran; Corresponding author.Department of Animal Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, IranFaculty of Biotechnology, Amol University of Special Modern Technologies, Amol, IranDepartment of Animal Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, IranDepartment of Animal Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, IranDepartment of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, IranSchizophrenia (SCZ) is a profound neurological disorder that affects approximately 1% of the global population. Alpha-pinene (α-pinene) is a natural and active monoterpene found in coniferous tree oil, primarily pine, with diverse pharmacological characteristics, including antioxidative, anxiolytic, and antidepressant properties. This research study delves into the neuroprotective effects of α-pinene on oxidative stress, memory deficits, and depressive and anxiety-like behaviors in a ketamine-induced mice model of SCZ using male mice. The mice were randomly divided into six groups: vehicle, control, positive control, ketamine, α-pinene at 50 mg/kg, and α-pinene at 100 mg/kg. Treatment of the ketamine-induced mice model of SCZ with α-pinene yielded significant improvements in depressive and anxiety-like behaviors and cognitive impairments. Furthermore, it significantly elevated glutathione (GSH) levels, total antioxidant capacity (TAC), dopamine levels, catalase (CAT), and superoxide dismutase (SOD) activities while markedly reducing malondialdehyde (MDA) levels. The current study establishes that α-pinene treatment effectively mitigates oxidative damage, cognitive deficits, and depressive and anxiogenic-like behaviors in the brains of ketamine-treated mice. Therefore, α-pinene treatment is an efficacious approach to forestall the neurobehavioral and neurobiochemical adverse effects of the ketamine-induced SCZ model of mice.http://www.sciencedirect.com/science/article/pii/S2667242123022984SchizophreniaAlpha-pineneKetamineOxidative stressMice |
| spellingShingle | Akbar Hajizadeh Moghaddam Fatemeh Malekzadeh Estalkhi Sedigheh Khanjani Jelodar Tabarek Ahmed Hasan Soroush Farhadi-Pahnedari Mohammad Karimian Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status IBRO Neuroscience Reports Schizophrenia Alpha-pinene Ketamine Oxidative stress Mice |
| title | Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status |
| title_full | Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status |
| title_fullStr | Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status |
| title_full_unstemmed | Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status |
| title_short | Neuroprotective effects of alpha-pinene against behavioral deficits in ketamine-induced mice model of schizophrenia: Focusing on oxidative stress status |
| title_sort | neuroprotective effects of alpha pinene against behavioral deficits in ketamine induced mice model of schizophrenia focusing on oxidative stress status |
| topic | Schizophrenia Alpha-pinene Ketamine Oxidative stress Mice |
| url | http://www.sciencedirect.com/science/article/pii/S2667242123022984 |
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