P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila
How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/11346 |
| _version_ | 1811227462040813568 |
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| author | Eric D Hoopfer Yonil Jung Hidehiko K Inagaki Gerald M Rubin David J Anderson |
| author_facet | Eric D Hoopfer Yonil Jung Hidehiko K Inagaki Gerald M Rubin David J Anderson |
| author_sort | Eric D Hoopfer |
| collection | DOAJ |
| description | How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner. |
| first_indexed | 2024-04-12T09:41:41Z |
| format | Article |
| id | doaj.art-f6953c8e893149c4af580ebf38dcb152 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:41:41Z |
| publishDate | 2015-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f6953c8e893149c4af580ebf38dcb1522022-12-22T03:38:03ZengeLife Sciences Publications LtdeLife2050-084X2015-12-01410.7554/eLife.11346P1 interneurons promote a persistent internal state that enhances inter-male aggression in DrosophilaEric D Hoopfer0Yonil Jung1Hidehiko K Inagaki2Gerald M Rubin3David J Anderson4Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, United StatesHow brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner.https://elifesciences.org/articles/11346aggressioncourtshipinternal statepersistencefruitlesssocial behavior |
| spellingShingle | Eric D Hoopfer Yonil Jung Hidehiko K Inagaki Gerald M Rubin David J Anderson P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila eLife aggression courtship internal state persistence fruitless social behavior |
| title | P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila |
| title_full | P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila |
| title_fullStr | P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila |
| title_full_unstemmed | P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila |
| title_short | P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila |
| title_sort | p1 interneurons promote a persistent internal state that enhances inter male aggression in drosophila |
| topic | aggression courtship internal state persistence fruitless social behavior |
| url | https://elifesciences.org/articles/11346 |
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