Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13–31)-Derived Peptides are Associated with Predicted α-Helical Propensity and Hydrophobic Index

Immunomodulatory Functions of the Human Cathelicidin LL-37 (aa 13–31)-Derived Peptides are Associated with Predicted α-Helical Propensity and Hydrophobic Index

The anti-endotoxin activity of the cationic peptide LL-37 and its derivative IG-19 is attributed to electrostatic interaction of the peptides’ positive charge with negatively charged bacterial lipopolysaccharides (LPS), and in part to the alteration of intracellular mechanisms independent...

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Bibliographic Details
Main Authors: Mahadevappa Hemshekhar, Sana Faiyaz, Ka-Yee Grace Choi, Oleg V. Krokhin, Neeloffer Mookherjee
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
cathelicidin
LL-37
IG-19
α-helicity
hydrophobicity
inflammation
immunomodulation
peptide retention time
Online Access:https://www.mdpi.com/2218-273X/9/9/501

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