Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure
Heart failure (HF), as the terminal stage of various heart diseases, seriously threatens an individual’s life, health, and quality of life. Emerging evidence has shown that the gut microbiota comprises an important component of human physiology and metabolic homeostasis, and can directly or indirect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/18/3758 |
| _version_ | 1797484035461611520 |
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| author | Peng Zhao Suhong Zhao Jinwei Tian Xinxin Liu |
| author_facet | Peng Zhao Suhong Zhao Jinwei Tian Xinxin Liu |
| author_sort | Peng Zhao |
| collection | DOAJ |
| description | Heart failure (HF), as the terminal stage of various heart diseases, seriously threatens an individual’s life, health, and quality of life. Emerging evidence has shown that the gut microbiota comprises an important component of human physiology and metabolic homeostasis, and can directly or indirectly affect the metabolic health of the host through metabolites. Upon in-depth study of intestinal microecology, the “gut-heart axis” appears to provide a novel direction for HF research. Thus, this review primarily focuses on the relationship between the gut microbiota and its major metabolites—i.e., short-chain fatty acids (SCFAs)—and HF. It explores the mechanisms underlying HF and its effective treatment by targeting SCFAs to optimize current HF treatment and thus improve the quality of patients’ lives. |
| first_indexed | 2024-03-09T22:56:41Z |
| format | Article |
| id | doaj.art-f6966cf691144cfa856312b6a3b9de9b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:56:41Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f6966cf691144cfa856312b6a3b9de9b2023-11-23T18:11:21ZengMDPI AGNutrients2072-66432022-09-011418375810.3390/nu14183758Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart FailurePeng Zhao0Suhong Zhao1Jinwei Tian2Xinxin Liu3Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, ChinaHeart failure (HF), as the terminal stage of various heart diseases, seriously threatens an individual’s life, health, and quality of life. Emerging evidence has shown that the gut microbiota comprises an important component of human physiology and metabolic homeostasis, and can directly or indirectly affect the metabolic health of the host through metabolites. Upon in-depth study of intestinal microecology, the “gut-heart axis” appears to provide a novel direction for HF research. Thus, this review primarily focuses on the relationship between the gut microbiota and its major metabolites—i.e., short-chain fatty acids (SCFAs)—and HF. It explores the mechanisms underlying HF and its effective treatment by targeting SCFAs to optimize current HF treatment and thus improve the quality of patients’ lives.https://www.mdpi.com/2072-6643/14/18/3758heart failuregut microbiotashort-chain fatty acidstreatment |
| spellingShingle | Peng Zhao Suhong Zhao Jinwei Tian Xinxin Liu Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure Nutrients heart failure gut microbiota short-chain fatty acids treatment |
| title | Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure |
| title_full | Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure |
| title_fullStr | Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure |
| title_full_unstemmed | Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure |
| title_short | Significance of Gut Microbiota and Short-Chain Fatty Acids in Heart Failure |
| title_sort | significance of gut microbiota and short chain fatty acids in heart failure |
| topic | heart failure gut microbiota short-chain fatty acids treatment |
| url | https://www.mdpi.com/2072-6643/14/18/3758 |
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