The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution
More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. He...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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eLife Sciences Publications Ltd
2015-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/09419 |
| _version_ | 1797692568456134656 |
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| author | Gui-Zhen Wang Xin Cheng Bo Zhou Zhe-Sheng Wen Yun-Chao Huang Hao-Bin Chen Gao-Feng Li Zhi-Liang Huang Yong-Chun Zhou Lin Feng Ming-Ming Wei Li-Wei Qu Yi Cao Guang-Biao Zhou |
| author_facet | Gui-Zhen Wang Xin Cheng Bo Zhou Zhe-Sheng Wen Yun-Chao Huang Hao-Bin Chen Gao-Feng Li Zhi-Liang Huang Yong-Chun Zhou Lin Feng Ming-Ming Wei Li-Wei Qu Yi Cao Guang-Biao Zhou |
| author_sort | Gui-Zhen Wang |
| collection | DOAJ |
| description | More than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13’s critical role in PAH-induced lung carcinogenesis. |
| first_indexed | 2024-03-12T02:30:29Z |
| format | Article |
| id | doaj.art-f697176384c749e7af2e774bb5c0259e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-12T02:30:29Z |
| publishDate | 2015-11-01 |
| publisher | eLife Sciences Publications Ltd |
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| series | eLife |
| spelling | doaj.art-f697176384c749e7af2e774bb5c0259e2023-09-05T08:26:56ZengeLife Sciences Publications LtdeLife2050-084X2015-11-01410.7554/eLife.09419The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollutionGui-Zhen Wang0Xin Cheng1Bo Zhou2Zhe-Sheng Wen3Yun-Chao Huang4Hao-Bin Chen5Gao-Feng Li6Zhi-Liang Huang7Yong-Chun Zhou8Lin Feng9Ming-Ming Wei10Li-Wei Qu11Yi Cao12Guang-Biao Zhou13State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaDepartment of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, The First People’s Hospital of Qu Jing City, Qu Jing, ChinaDepartment of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, ChinaDepartment of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Pathology, Chinese PLA General Hospital, Beijing, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaLaboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaMore than 90% of lung cancers are caused by cigarette smoke and air pollution, with polycyclic aromatic hydrocarbons (PAHs) as key carcinogens. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China, attributed to smoky coal combustion-generated PAH pollution. Here, we screened for abnormal inflammatory factors in non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used, and found that a chemokine CXCL13 was overexpressed in 63/70 (90%) of Xuanwei NSCLCs and 44/71 (62%) of smoker and 27/60 (45%) of non-smoker CR patients. CXCL13 overexpression was associated with the region Xuanwei and cigarette smoke. The key carcinogen benzo(a)pyrene (BaP) induced CXCL13 production in lung epithelial cells and in mice prior to development of detectable lung cancer. Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13’s critical role in PAH-induced lung carcinogenesis.https://elifesciences.org/articles/09419CXCL13environmental pollutantlung cancer |
| spellingShingle | Gui-Zhen Wang Xin Cheng Bo Zhou Zhe-Sheng Wen Yun-Chao Huang Hao-Bin Chen Gao-Feng Li Zhi-Liang Huang Yong-Chun Zhou Lin Feng Ming-Ming Wei Li-Wei Qu Yi Cao Guang-Biao Zhou The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution eLife CXCL13 environmental pollutant lung cancer |
| title | The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution |
| title_full | The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution |
| title_fullStr | The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution |
| title_full_unstemmed | The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution |
| title_short | The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution |
| title_sort | chemokine cxcl13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution |
| topic | CXCL13 environmental pollutant lung cancer |
| url | https://elifesciences.org/articles/09419 |
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