Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer to Radiation Therapy through Oxidative Activation of the JNK Apoptotic Pathway

Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer to Radiation Therapy through Oxidative Activation of the JNK Apoptotic Pathway

Side effects of radiation therapy (RT) remain the most challenging issue for pancreatic cancer treatment. Cerium oxide nanoparticles (CONPs) are currently being tested in pre-clinical trials as an adjuvant to sensitize pancreatic cancer cells to RT and protect normal tissues from the harmful side ef...

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Bibliographic Details
Main Authors: Melissa S. Wason, Heng Lu, Lin Yu, Satadru K. Lahiri, Debarati Mukherjee, Chao Shen, Soumen Das, Sudipta Seal, Jihe Zhao
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
cerium oxide nanoparticles
radiation therapy
cancer
thioredoxin 1
JNK
apoptosis
Online Access:http://www.mdpi.com/2072-6694/10/9/303

Internet

http://www.mdpi.com/2072-6694/10/9/303

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