A Novel Tongue Squamous Cell Carcinoma Cell Line Escapes from Immune Recognition due to Genetic Alterations in <i>HLA</i> Class I Complex

A Novel Tongue Squamous Cell Carcinoma Cell Line Escapes from Immune Recognition due to Genetic Alterations in <i>HLA</i> Class I Complex

Immune checkpoint inhibitors (ICI) have made progress in the field of anticancer treatment, but a certain number of PD-L1 negative OSCC patients still have limited benefits from ICI immuno-therapy because of primary immune evasion due to immunodeficiency. However, in existing human OSCC cell lines,...

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Bibliographic Details
Main Authors: Xiaofeng Zheng, Yanan Sun, Yiwei Li, Jiyuan Ma, Yinan Lv, Yaying Hu, Yi Zhou, Jiali Zhang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
HLA class I complex
<i>B2M</i>
tongue squamous cell carcinoma
immune recognition
PD-L1
Online Access:https://www.mdpi.com/2073-4409/12/1/35

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