Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing
Neutrophils play a critical role in the immune response to infection and tissue injury. However, recent studies have shown that neutrophils are a heterogeneous population with distinct subtypes that differ in their functional properties. Moreover, aging can alter neutrophil function and exacerbate i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201651/full |
| _version_ | 1797449248921354240 |
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| author | Yi Liu Changlan Xiang Zhenni Que Chenglong Li Wen Wang Lijuan Yin Chenyu Chu Yin Zhou |
| author_facet | Yi Liu Changlan Xiang Zhenni Que Chenglong Li Wen Wang Lijuan Yin Chenyu Chu Yin Zhou |
| author_sort | Yi Liu |
| collection | DOAJ |
| description | Neutrophils play a critical role in the immune response to infection and tissue injury. However, recent studies have shown that neutrophils are a heterogeneous population with distinct subtypes that differ in their functional properties. Moreover, aging can alter neutrophil function and exacerbate immune dysregulation. In this review, we discuss the concept of neutrophil heterogeneity and how it may be affected by aging. We then examine the implications of neutrophil heterogeneity and aging for COVID-19 pathogenesis and wound healing. Specifically, we summarize the evidence for neutrophil involvement in COVID-19 and the potential mechanisms underlying neutrophil recruitment and activation in this disease. We also review the literature on the role of neutrophils in the wound healing process and how aging and neutrophil heterogeneity may impact wound healing outcomes. Finally, we discuss the potential for neutrophil-targeted therapies to improve clinical outcomes in COVID-19 and wound healing. |
| first_indexed | 2024-03-09T14:22:09Z |
| format | Article |
| id | doaj.art-f69b8a81f8cb4af493c79c209281b3c7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T14:22:09Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f69b8a81f8cb4af493c79c209281b3c72023-11-28T10:05:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-11-011410.3389/fimmu.2023.12016511201651Neutrophil heterogeneity and aging: implications for COVID-19 and wound healingYi LiuChanglan XiangZhenni QueChenglong LiWen WangLijuan YinChenyu ChuYin ZhouNeutrophils play a critical role in the immune response to infection and tissue injury. However, recent studies have shown that neutrophils are a heterogeneous population with distinct subtypes that differ in their functional properties. Moreover, aging can alter neutrophil function and exacerbate immune dysregulation. In this review, we discuss the concept of neutrophil heterogeneity and how it may be affected by aging. We then examine the implications of neutrophil heterogeneity and aging for COVID-19 pathogenesis and wound healing. Specifically, we summarize the evidence for neutrophil involvement in COVID-19 and the potential mechanisms underlying neutrophil recruitment and activation in this disease. We also review the literature on the role of neutrophils in the wound healing process and how aging and neutrophil heterogeneity may impact wound healing outcomes. Finally, we discuss the potential for neutrophil-targeted therapies to improve clinical outcomes in COVID-19 and wound healing.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201651/fullneutrophilagingheterogeneityCOVID-19wound healingimmune response |
| spellingShingle | Yi Liu Changlan Xiang Zhenni Que Chenglong Li Wen Wang Lijuan Yin Chenyu Chu Yin Zhou Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing Frontiers in Immunology neutrophil aging heterogeneity COVID-19 wound healing immune response |
| title | Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing |
| title_full | Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing |
| title_fullStr | Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing |
| title_full_unstemmed | Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing |
| title_short | Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing |
| title_sort | neutrophil heterogeneity and aging implications for covid 19 and wound healing |
| topic | neutrophil aging heterogeneity COVID-19 wound healing immune response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201651/full |
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