Computed tomographic findings in dogs with multiple myeloma
Abstract Background Computed tomography (CT) is considered the first‐line imaging modality for human patients with suspected multiple myeloma (MM). Recently the diagnostic criteria for human MM have been updated. Objectives To describe and provide a baseline of the CT features and distribution of os...
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Veterinary Medicine and Science |
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| Online Access: | https://doi.org/10.1002/vms3.1019 |
| _version_ | 1797866270436098048 |
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| author | Sven‐Erik Hõim Ella Fitzgerald Emma Mapletoft Katarzyna Purzycka |
| author_facet | Sven‐Erik Hõim Ella Fitzgerald Emma Mapletoft Katarzyna Purzycka |
| author_sort | Sven‐Erik Hõim |
| collection | DOAJ |
| description | Abstract Background Computed tomography (CT) is considered the first‐line imaging modality for human patients with suspected multiple myeloma (MM). Recently the diagnostic criteria for human MM have been updated. Objectives To describe and provide a baseline of the CT features and distribution of osseous lesions in dogs diagnosed with MM and to describe the change of initial osseous lesions after the start of treatment in a subset of dogs. Methods Single‐centre, retrospective, descriptive, case series. Dogs were included when they met the updated MM criteria and if a staging CT was performed at the time of diagnosis and prior to initiation of treatment. When available, change of osseous lesions was assessed on serial imaging studies. Results Thirteen dogs met the inclusion criteria. All dogs had involvement of the axial skeleton and 9/13 (69%) had concurrent involvement of the appendicular skeleton. Large (≥1 cm), lytic, ‘punched out’ or expansile bony lesions and regions of permeative lysis were most common and mainly affected the vertebral column. Discrete intramedullary soft tissue attenuating lesions of the proximal appendicular skeleton were observed in 8/13 dogs (61%) and bilateral involvement of both humeri and femurs was seen in 4/9 dogs (44%). A subset of dogs underwent serial imaging and progressive replacement of the contrast‐enhancing lesions with fat attenuating tissue was observed for all dogs, corresponding with clinical improvement. Conclusions This case series provides a baseline knowledge of the initial and follow‐up CT features in dogs diagnosed with MM based on updated criteria. |
| first_indexed | 2024-04-09T23:22:30Z |
| format | Article |
| id | doaj.art-f69ce205e5614341aa13481477d05367 |
| institution | Directory Open Access Journal |
| issn | 2053-1095 |
| language | English |
| last_indexed | 2024-04-09T23:22:30Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj.art-f69ce205e5614341aa13481477d053672023-03-21T15:53:53ZengWileyVeterinary Medicine and Science2053-10952023-03-019266066910.1002/vms3.1019Computed tomographic findings in dogs with multiple myelomaSven‐Erik Hõim0Ella Fitzgerald1Emma Mapletoft2Katarzyna Purzycka3Diagnostic Imaging Department Anderson Moores Veterinary Specialists Part of Linnaeus Veterinary Limited The Granary Bunstead Barns Poles Ln Winchester UKANTECH Imaging Services Fountain Valley CaliforniaDiagnostic Imaging Department Queen Mother Hospital for Animals Royal Veterinary College North Mymms Hertfordshire UKOncology Department Lumbry Park Veterinary Specialists Alton Hampshire UKAbstract Background Computed tomography (CT) is considered the first‐line imaging modality for human patients with suspected multiple myeloma (MM). Recently the diagnostic criteria for human MM have been updated. Objectives To describe and provide a baseline of the CT features and distribution of osseous lesions in dogs diagnosed with MM and to describe the change of initial osseous lesions after the start of treatment in a subset of dogs. Methods Single‐centre, retrospective, descriptive, case series. Dogs were included when they met the updated MM criteria and if a staging CT was performed at the time of diagnosis and prior to initiation of treatment. When available, change of osseous lesions was assessed on serial imaging studies. Results Thirteen dogs met the inclusion criteria. All dogs had involvement of the axial skeleton and 9/13 (69%) had concurrent involvement of the appendicular skeleton. Large (≥1 cm), lytic, ‘punched out’ or expansile bony lesions and regions of permeative lysis were most common and mainly affected the vertebral column. Discrete intramedullary soft tissue attenuating lesions of the proximal appendicular skeleton were observed in 8/13 dogs (61%) and bilateral involvement of both humeri and femurs was seen in 4/9 dogs (44%). A subset of dogs underwent serial imaging and progressive replacement of the contrast‐enhancing lesions with fat attenuating tissue was observed for all dogs, corresponding with clinical improvement. Conclusions This case series provides a baseline knowledge of the initial and follow‐up CT features in dogs diagnosed with MM based on updated criteria.https://doi.org/10.1002/vms3.1019computed tomographydogmultiple myeloma |
| spellingShingle | Sven‐Erik Hõim Ella Fitzgerald Emma Mapletoft Katarzyna Purzycka Computed tomographic findings in dogs with multiple myeloma Veterinary Medicine and Science computed tomography dog multiple myeloma |
| title | Computed tomographic findings in dogs with multiple myeloma |
| title_full | Computed tomographic findings in dogs with multiple myeloma |
| title_fullStr | Computed tomographic findings in dogs with multiple myeloma |
| title_full_unstemmed | Computed tomographic findings in dogs with multiple myeloma |
| title_short | Computed tomographic findings in dogs with multiple myeloma |
| title_sort | computed tomographic findings in dogs with multiple myeloma |
| topic | computed tomography dog multiple myeloma |
| url | https://doi.org/10.1002/vms3.1019 |
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