Small Paroxysmal Nocturnal Hemoglobinuria Clones in Autoimmune Hemolytic Anemia: Clinical Implications and Different Cytokine Patterns in Positive and Negative Patients

Small Paroxysmal Nocturnal Hemoglobinuria Clones in Autoimmune Hemolytic Anemia: Clinical Implications and Different Cytokine Patterns in Positive and Negative Patients

Autoimmune hemolytic anemia (AIHA) is characterized by immune mediated erythrocytes destruction by autoantibodies with or without complement activation. Additional pathologic mechanisms include cellular cytotoxicity, cytokline dysregulation, and inadequate bone marrow compensation with fibrosis/dyse...

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Bibliographic Details
Main Authors: Bruno Fattizzo, Juri Giannotta, Anna Zaninoni, Austin Kulasekararaj, Lilla Cro, Wilma Barcellini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
warm autoimmune hemolytic anemia
cold agglutinin disease
paroxysmal nocturnal hemoglobinuria
rituximab
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01006/full

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