Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome
Posterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria describe relative sparing of episodic memory function, but recent findings sugg...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218300780 |
| _version_ | 1818311488785350656 |
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| author | Samrah Ahmed Muireann Irish Clare Loane Ian Baker Masud Husain Sian Thompson Cristina Blanco-Duque Clare Mackay Giovanna Zamboni David Foxe John R. Hodges Olivier Piguet Christopher Butler |
| author_facet | Samrah Ahmed Muireann Irish Clare Loane Ian Baker Masud Husain Sian Thompson Cristina Blanco-Duque Clare Mackay Giovanna Zamboni David Foxe John R. Hodges Olivier Piguet Christopher Butler |
| author_sort | Samrah Ahmed |
| collection | DOAJ |
| description | Posterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria describe relative sparing of episodic memory function, but recent findings suggest that anterograde memory is often impaired. Whether these deficits extend to remote memory has not been addressed. A large body of evidence suggests that the recollection of an autobiographical event from the remote past coincides with the successful retrieval of visual images. We hypothesised that the profound visual processing deficits in posterior cortical atrophy would result in impaired autobiographical memory retrieval. Fourteen posterior cortical atrophy patients, eighteen typical Alzheimer's disease patients and twenty-eight healthy controls completed the Autobiographical Interview. Autobiographical memory in posterior cortical atrophy was characterised by a striking loss of internal, episodic detail relative to controls and to same extent as typical Alzheimer's disease patients, in conjunction with an increase in external details tangential to the memory described. The memory narratives of posterior cortical atrophy patients showed a specific reduction in spatiotemporal and perceptual detail. Voxel-based morphometry analysis revealed atrophy of the parieto-occipital cortices in posterior cortical atrophy but relatively spared hippocampi bilaterally, compared with characteristic atrophy of the medial temporal lobes in typical Alzheimer's disease. Analysis of brain regions showing posterior cortical atrophy-specific atrophy revealed a correlation between perceptual details in autobiographical memory and grey matter density in the right precuneus. This study demonstrates remote memory impairment in posterior cortical atrophy despite relatively preserved medial temporal lobe structures. The results demonstrate, for the first time, profound autobiographical memory impairment in PCA and suggest that this is driven by the well-recognised deficits in higher-order visual processing. The findings are discussed in the context of posterior parietal contributions to imagery and memory, and the clinical implications of autobiographical memory impairment for diagnostic and management protocols in posterior cortical atrophy. Keywords: Posterior cortical atrophy, Autobiographical memory, Visual imagery, Alzheimer's disease |
| first_indexed | 2024-12-13T08:02:46Z |
| format | Article |
| id | doaj.art-f69e3473ebf5469faf5360be24f13705 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-13T08:02:46Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-f69e3473ebf5469faf5360be24f137052022-12-21T23:54:23ZengElsevierNeuroImage: Clinical2213-15822018-01-0118822834Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndromeSamrah Ahmed0Muireann Irish1Clare Loane2Ian Baker3Masud Husain4Sian Thompson5Cristina Blanco-Duque6Clare Mackay7Giovanna Zamboni8David Foxe9John R. Hodges10Olivier Piguet11Christopher Butler12Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK; Corresponding author at: Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU Oxford, UK.The University of Sydney, School of Psychology and Brain & Mind Centre, Sydney, Australia; Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, AustraliaNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UKRussell Cairns Unit, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UKNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK; Department of Experimental Psychology, University of Oxford, John Radcliffe Hospital, Oxford, UKDepartment of Clinical Neurology, Oxford University Hospitals NHS Trust, Oxford, UKDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UKDepartment of Psychiatry, University of Oxford, Oxford, UKNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UKThe University of Sydney, School of Psychology and Brain & Mind Centre, Sydney, AustraliaAustralian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, Australia; The University of Sydney, Clinical Medical School and Brain & Mind Centre, Sydney, AustraliaThe University of Sydney, School of Psychology and Brain & Mind Centre, Sydney, Australia; Australian Research Council Centre of Excellence in Cognition and its Disorders, Sydney, AustraliaNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UKPosterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria describe relative sparing of episodic memory function, but recent findings suggest that anterograde memory is often impaired. Whether these deficits extend to remote memory has not been addressed. A large body of evidence suggests that the recollection of an autobiographical event from the remote past coincides with the successful retrieval of visual images. We hypothesised that the profound visual processing deficits in posterior cortical atrophy would result in impaired autobiographical memory retrieval. Fourteen posterior cortical atrophy patients, eighteen typical Alzheimer's disease patients and twenty-eight healthy controls completed the Autobiographical Interview. Autobiographical memory in posterior cortical atrophy was characterised by a striking loss of internal, episodic detail relative to controls and to same extent as typical Alzheimer's disease patients, in conjunction with an increase in external details tangential to the memory described. The memory narratives of posterior cortical atrophy patients showed a specific reduction in spatiotemporal and perceptual detail. Voxel-based morphometry analysis revealed atrophy of the parieto-occipital cortices in posterior cortical atrophy but relatively spared hippocampi bilaterally, compared with characteristic atrophy of the medial temporal lobes in typical Alzheimer's disease. Analysis of brain regions showing posterior cortical atrophy-specific atrophy revealed a correlation between perceptual details in autobiographical memory and grey matter density in the right precuneus. This study demonstrates remote memory impairment in posterior cortical atrophy despite relatively preserved medial temporal lobe structures. The results demonstrate, for the first time, profound autobiographical memory impairment in PCA and suggest that this is driven by the well-recognised deficits in higher-order visual processing. The findings are discussed in the context of posterior parietal contributions to imagery and memory, and the clinical implications of autobiographical memory impairment for diagnostic and management protocols in posterior cortical atrophy. Keywords: Posterior cortical atrophy, Autobiographical memory, Visual imagery, Alzheimer's diseasehttp://www.sciencedirect.com/science/article/pii/S2213158218300780 |
| spellingShingle | Samrah Ahmed Muireann Irish Clare Loane Ian Baker Masud Husain Sian Thompson Cristina Blanco-Duque Clare Mackay Giovanna Zamboni David Foxe John R. Hodges Olivier Piguet Christopher Butler Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome NeuroImage: Clinical |
| title | Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome |
| title_full | Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome |
| title_fullStr | Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome |
| title_full_unstemmed | Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome |
| title_short | Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome |
| title_sort | association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy beyond the visual syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218300780 |
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