Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to understand in vivo protection of PfCSP-targeting ant...
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Détails bibliographiques
| Auteurs principaux: |
Tossapol Pholcharee,
David Oyen,
Yevel Flores-Garcia,
Gonzalo Gonzalez-Paez,
Zhen Han,
Katherine L. Williams,
Wayne Volkmuth,
Daniel Emerling,
Emily Locke,
C. Richter King,
Fidel Zavala,
Ian A. Wilson |
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| Format: | Article
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| Langue: | English |
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| Publié: |
Nature Portfolio
2021-02-01
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| Collection: | Nature Communications
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| Accès en ligne: | https://doi.org/10.1038/s41467-021-21221-4
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