Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma

Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma

Abstract The epithelial‐to‐mesenchymal transition (EMT) plays a central role in the development of cancer metastasis and resistance to chemotherapy. However, its pharmacological treatment remains challenging. Here, we used an EMT‐focused integrative functional genomic approach and identified an inve...

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Main Authors: Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal‐Egaña, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Færgeman, Ole N Jensen, Rasmus Siersbæk, Kumar Somyajit, Paolo Ceppi
Format: Article
Language:English
Published: Springer Nature 2023-12-01
Series:EMBO Molecular Medicine
Subjects:
epithelial–mesenchymal transition
H3K27 acetylation
metastasis
metabolic inhibitor
propionate
Online Access:https://doi.org/10.15252/emmm.202317836

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