Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review
Sepsis is the main cause of death among patients admitted to intensive care units. Management of sepsis includes fluid resuscitation, vasopressors, intravenous antimicrobials, source control, mechanical ventilation, and others. New insights into the potential benefits of non-antimicrobial drugs in s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1143090/full |
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| author | Lou'i Al-Husinat Amer Abu Hmaid Hadeel Abbas Batool Abuelsamen Mutaz Albelbisi Said Haddad Ibrahim Qamileh Ossaid Quneis Zaid Jehad Al Modanat Giuseppe Ferrara Fernando Suparregui Dias Gilda Cinnella |
| author_facet | Lou'i Al-Husinat Amer Abu Hmaid Hadeel Abbas Batool Abuelsamen Mutaz Albelbisi Said Haddad Ibrahim Qamileh Ossaid Quneis Zaid Jehad Al Modanat Giuseppe Ferrara Fernando Suparregui Dias Gilda Cinnella |
| author_sort | Lou'i Al-Husinat |
| collection | DOAJ |
| description | Sepsis is the main cause of death among patients admitted to intensive care units. Management of sepsis includes fluid resuscitation, vasopressors, intravenous antimicrobials, source control, mechanical ventilation, and others. New insights into the potential benefits of non-antimicrobial drugs in sepsis have evolved based on the pathophysiology of the disease and the mechanism of action of some drugs, but the findings are still controversial. In this study, we aimed to evaluate the effect of beta-blockers, aspirin, statins, and heparin as adjunctive treatments in septic patients under mechanical ventilation with non-cardiovascular diseases and their effect on mortality. We searched PubMed with relevant keywords (beta-blockers, aspirin, statins, or heparin, and critically ill or sepsis) for the last 10 years and some personal collection of relevant articles, and then we assessed studies according to prespecified inclusion and exclusion criteria. Our results show that beta-blockers, aspirin, and heparin may have promising feedback on reducing mortality. However, new well-controlled, randomized, multicenter studies are needed to confirm that, and multiple issues regarding their usage need to be addressed. On the other hand, the feedback regarding the effectiveness of statins was not as strong as that of the other drugs studied, and we suggest that further research is needed to confirm these results. |
| first_indexed | 2024-03-13T00:32:29Z |
| format | Article |
| id | doaj.art-f6a1c02493524ea78d35e1d9ee28e0d9 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T00:32:29Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-f6a1c02493524ea78d35e1d9ee28e0d92023-07-10T12:43:27ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-07-011010.3389/fmed.2023.11430901143090Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative reviewLou'i Al-Husinat0Amer Abu Hmaid1Hadeel Abbas2Batool Abuelsamen3Mutaz Albelbisi4Said Haddad5Ibrahim Qamileh6Ossaid Quneis7Zaid Jehad Al Modanat8Giuseppe Ferrara9Fernando Suparregui Dias10Gilda Cinnella11Department of Clinical Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, JordanFaculty of Medicine, Yarmouk University, Irbid, JordanFaculty of Medicine, Yarmouk University, Irbid, JordanFaculty of Medicine, Yarmouk University, Irbid, JordanFaculty of Medicine, Yarmouk University, Irbid, JordanFaculty of Medicine, Jordan University of Science and Technology, Irbid, JordanDepartment of Anesthesia and Intensive Care, Al-Maqasid Charity Hospital, Amman, JordanFaculty of Medicine, Yarmouk University, Irbid, JordanDepartment of Clinical Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, JordanDepartment of Anesthesia and Intensive Care, University of Foggia, Foggia, ItalyDepartment of Intensive Care, Hospital São Lucas da PUCRS, Porto Alegre, BrazilDepartment of Anesthesia and Intensive Care, University of Foggia, Foggia, ItalySepsis is the main cause of death among patients admitted to intensive care units. Management of sepsis includes fluid resuscitation, vasopressors, intravenous antimicrobials, source control, mechanical ventilation, and others. New insights into the potential benefits of non-antimicrobial drugs in sepsis have evolved based on the pathophysiology of the disease and the mechanism of action of some drugs, but the findings are still controversial. In this study, we aimed to evaluate the effect of beta-blockers, aspirin, statins, and heparin as adjunctive treatments in septic patients under mechanical ventilation with non-cardiovascular diseases and their effect on mortality. We searched PubMed with relevant keywords (beta-blockers, aspirin, statins, or heparin, and critically ill or sepsis) for the last 10 years and some personal collection of relevant articles, and then we assessed studies according to prespecified inclusion and exclusion criteria. Our results show that beta-blockers, aspirin, and heparin may have promising feedback on reducing mortality. However, new well-controlled, randomized, multicenter studies are needed to confirm that, and multiple issues regarding their usage need to be addressed. On the other hand, the feedback regarding the effectiveness of statins was not as strong as that of the other drugs studied, and we suggest that further research is needed to confirm these results.https://www.frontiersin.org/articles/10.3389/fmed.2023.1143090/fullsepsisaspirinbeta-blockerstatinheparin |
| spellingShingle | Lou'i Al-Husinat Amer Abu Hmaid Hadeel Abbas Batool Abuelsamen Mutaz Albelbisi Said Haddad Ibrahim Qamileh Ossaid Quneis Zaid Jehad Al Modanat Giuseppe Ferrara Fernando Suparregui Dias Gilda Cinnella Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review Frontiers in Medicine sepsis aspirin beta-blocker statin heparin |
| title | Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review |
| title_full | Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review |
| title_fullStr | Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review |
| title_full_unstemmed | Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review |
| title_short | Role of aspirin, beta-blocker, statins, and heparin therapy in septic patients under mechanical ventilation: a narrative review |
| title_sort | role of aspirin beta blocker statins and heparin therapy in septic patients under mechanical ventilation a narrative review |
| topic | sepsis aspirin beta-blocker statin heparin |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1143090/full |
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