Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis.
Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-09-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941393/?tool=EBI |
| _version_ | 1828795271743537152 |
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| author | Nathan W Gouwens Hugo Zeberg Kunichika Tsumoto Takashi Tateno Kazuyuki Aihara Hugh P C Robinson |
| author_facet | Nathan W Gouwens Hugo Zeberg Kunichika Tsumoto Takashi Tateno Kazuyuki Aihara Hugh P C Robinson |
| author_sort | Nathan W Gouwens |
| collection | DOAJ |
| description | Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF), describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively. |
| first_indexed | 2024-12-12T04:01:41Z |
| format | Article |
| id | doaj.art-f6a1e49bc8b24eee87162c4efe1f3288 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-12T04:01:41Z |
| publishDate | 2010-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-f6a1e49bc8b24eee87162c4efe1f32882022-12-22T00:39:02ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582010-09-0169e100095110.1371/journal.pcbi.1000951Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. Nathan W GouwensHugo ZebergKunichika TsumotoTakashi TatenoKazuyuki AiharaHugh P C RobinsonFast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF), describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941393/?tool=EBI |
| spellingShingle | Nathan W Gouwens Hugo Zeberg Kunichika Tsumoto Takashi Tateno Kazuyuki Aihara Hugh P C Robinson Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. PLoS Computational Biology |
| title | Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. |
| title_full | Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. |
| title_fullStr | Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. |
| title_full_unstemmed | Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. |
| title_short | Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. |
| title_sort | synchronization of firing in cortical fast spiking interneurons at gamma frequencies a phase resetting analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941393/?tool=EBI |
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