The effect of chlorhexidine on Acinetobacter baumannii in intensive care units
Background and Objectives: Measures to prevent the emergence of hospital-acquired infections (HAIs) include a daily bath with chlorhexidine gluconate (CHG). The aim of this study was to determine the effect of patients bathing daily with CHG on the bacterial colonization on patient surfaces, enviro...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-02-01
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| Series: | Iranian Journal of Microbiology |
| Subjects: | |
| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/2859 |
| _version_ | 1819061262779154432 |
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| author | Michel F. Martinez-Resendez Flora Cruz-López Natalia Gaona-Chávez Adrián Camacho-Ortiz Roberto Mercado-Longoria Samantha Flores-Treviño Paola Bocanegra-Ibarias Elvira Garza-González |
| author_facet | Michel F. Martinez-Resendez Flora Cruz-López Natalia Gaona-Chávez Adrián Camacho-Ortiz Roberto Mercado-Longoria Samantha Flores-Treviño Paola Bocanegra-Ibarias Elvira Garza-González |
| author_sort | Michel F. Martinez-Resendez |
| collection | DOAJ |
| description |
Background and Objectives: Measures to prevent the emergence of hospital-acquired infections (HAIs) include a daily bath with chlorhexidine gluconate (CHG). The aim of this study was to determine the effect of patients bathing daily with CHG on the bacterial colonization on patient surfaces, environmental surrounding areas, and attending healthcare workers (HCWs).
Materials and Methods: Patients were randomized by a 1:1 in two groups. Patients in group 1 were bathed daily with CHG; patients in group 2 were bathed with a placebo. Microbiological sampling of patients, environment, and HCWs were carried out on days 0, 3, and 10. The clonal relatedness of selected isolates collected was determined through pulsed-field gel electrophoresis. Clinical and demographic data were obtained from medical files.
Results: Thirty-three patients were included (18 in group 1 and 15 in group 2). The more common species was Acinetobacter baumannii (n=144), followed by Klebsiella pneumoniae (n=81). A. baumannii was isolated more frequently on environmental surfaces in group 2 than group 1 (day 0 vs. day 3 vs. day 10; p = 0.0388). Twelve clones of A. baumannii were detected, with predominant clone A detected in patients and environmental surfaces. No pathogens were detected in HCWs.
Conclusion: Our data support that CHG bathing decreases A. baumannii surviving on the environmental surfaces of critically ill patients.
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| first_indexed | 2024-12-21T14:40:06Z |
| format | Article |
| id | doaj.art-f6a21bde5bb646d3ad61511ffd76d9ac |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-21T14:40:06Z |
| publishDate | 2022-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-f6a21bde5bb646d3ad61511ffd76d9ac2022-12-21T19:00:12ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472022-02-0114110.18502/ijm.v14i1.8796The effect of chlorhexidine on Acinetobacter baumannii in intensive care unitsMichel F. Martinez-Resendez0Flora Cruz-López1Natalia Gaona-Chávez2Adrián Camacho-Ortiz3Roberto Mercado-Longoria4Samantha Flores-Treviño5Paola Bocanegra-Ibarias6Elvira Garza-González7Department of Internal Medicine, University Hospital ‘Dr. José Eleuterio González’, Autonomous University of Nuevo Leon, Monterrey, Nue vo León, MexicoDepartment of Pharmaceutical Biological Chemistry, School of Chemistry, Autonomous University of Nuevo Leon, San Nicolas de los Garza, Nuevo León, MexicoDepartment of Internal Medicine, University Hospital ‘Dr. José Eleuterio González’, Autonomous University of Nuevo Leon, Monterrey, Nue vo León, MexicoDepartment of Internal Medicine, University Hospital ‘Dr. José Eleuterio González’, Autonomous University of Nuevo Leon, Monterrey, Nue vo León, MexicoDepartment of Internal Medicine, University Hospital ‘Dr. José Eleuterio González’, Autonomous University of Nuevo Leon, Monterrey, Nue vo León, MexicoDepartment of Internal Medicine, University Hospital ‘Dr. José Eleuterio González’, Autonomous University of Nuevo Leon, Monterrey, Nue vo León, MexicoDepartment of Internal Medicine, University Hospital ‘Dr. José Eleuterio González’, Autonomous University of Nuevo Leon, Monterrey, Nue vo León, MexicoDepartment of Biochemistry and Molecular Medicine, School of Medicine, University Hospital ‘Dr. José Eleuterio González’, Autonomous University of Nuevo Leon, Monterrey, Nue vo León, Mexico Background and Objectives: Measures to prevent the emergence of hospital-acquired infections (HAIs) include a daily bath with chlorhexidine gluconate (CHG). The aim of this study was to determine the effect of patients bathing daily with CHG on the bacterial colonization on patient surfaces, environmental surrounding areas, and attending healthcare workers (HCWs). Materials and Methods: Patients were randomized by a 1:1 in two groups. Patients in group 1 were bathed daily with CHG; patients in group 2 were bathed with a placebo. Microbiological sampling of patients, environment, and HCWs were carried out on days 0, 3, and 10. The clonal relatedness of selected isolates collected was determined through pulsed-field gel electrophoresis. Clinical and demographic data were obtained from medical files. Results: Thirty-three patients were included (18 in group 1 and 15 in group 2). The more common species was Acinetobacter baumannii (n=144), followed by Klebsiella pneumoniae (n=81). A. baumannii was isolated more frequently on environmental surfaces in group 2 than group 1 (day 0 vs. day 3 vs. day 10; p = 0.0388). Twelve clones of A. baumannii were detected, with predominant clone A detected in patients and environmental surfaces. No pathogens were detected in HCWs. Conclusion: Our data support that CHG bathing decreases A. baumannii surviving on the environmental surfaces of critically ill patients. https://ijm.tums.ac.ir/index.php/ijm/article/view/2859Infection disease transmission;Chlorhexidine;Decontamination;Acinetobacter baumannii;Gram-negative bacteria |
| spellingShingle | Michel F. Martinez-Resendez Flora Cruz-López Natalia Gaona-Chávez Adrián Camacho-Ortiz Roberto Mercado-Longoria Samantha Flores-Treviño Paola Bocanegra-Ibarias Elvira Garza-González The effect of chlorhexidine on Acinetobacter baumannii in intensive care units Iranian Journal of Microbiology Infection disease transmission; Chlorhexidine; Decontamination; Acinetobacter baumannii; Gram-negative bacteria |
| title | The effect of chlorhexidine on Acinetobacter baumannii in intensive care units |
| title_full | The effect of chlorhexidine on Acinetobacter baumannii in intensive care units |
| title_fullStr | The effect of chlorhexidine on Acinetobacter baumannii in intensive care units |
| title_full_unstemmed | The effect of chlorhexidine on Acinetobacter baumannii in intensive care units |
| title_short | The effect of chlorhexidine on Acinetobacter baumannii in intensive care units |
| title_sort | effect of chlorhexidine on acinetobacter baumannii in intensive care units |
| topic | Infection disease transmission; Chlorhexidine; Decontamination; Acinetobacter baumannii; Gram-negative bacteria |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/2859 |
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