The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and design
Abstract Background Mental stress-induced myocardial ischemia (MSIMI) frequently occurs in patients with coronary artery disease (CAD), and is even more common in patients with co-occurring CAD and depression/anxiety. MSIMI appears to be a poor prognostic factor for CAD, but existing data on depress...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03246-3 |
| _version_ | 1797832262588301312 |
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| author | Nan Nan Lei Feng Wei Dong Bingyu Gao Huijuan Zuo Hongzhi Mi Gang Wang Xiantao Song Hongjia Zhang |
| author_facet | Nan Nan Lei Feng Wei Dong Bingyu Gao Huijuan Zuo Hongzhi Mi Gang Wang Xiantao Song Hongjia Zhang |
| author_sort | Nan Nan |
| collection | DOAJ |
| description | Abstract Background Mental stress-induced myocardial ischemia (MSIMI) frequently occurs in patients with coronary artery disease (CAD), and is even more common in patients with co-occurring CAD and depression/anxiety. MSIMI appears to be a poor prognostic factor for CAD, but existing data on depression/anxiety patients are limited. Methods This cohort study will consecutively screen 2,647 CAD patients between 2023 and 2025. Included subjects will need to have received coronary revascularization and also have depression and/or anxiety at baseline. This study will enroll 360 subjects who meet the criteria. Two mental stress tests will be carried out in each patient at 1 month and 1 year timelines after coronary revascularization, using Stroop color word tests. MSIMI will be assessed by 99 m−Tc-sestamibi myocardial perfusion imaging. The endothelial function will be assessed by EndoPAT. Furthermore, we will dynamically monitor patients’ health and mental conditions every 3 months. The mean follow-up time will be 1 year. The primary endpoint is the major adverse cardiac events, a composite of all-cause death, cardiac death, myocardial infarction, stroke, or unplanned revascularization. Secondary endpoints will include overall health and mental conditions. The reproducibility of mental stress combined with myocardial perfusion for detecting MSIMI and comparisons between coronary stenosis and ischemic segments will also be included. Conclusions This cohort study will provide information on MSIMI outcomes in CAD patients who also have comorbid depression/anxiety after revascularization. In addition, understanding the long-term dynamics of MSIMI and the match between coronary stenosis and ischemia will provide insight into MSIMI mechanisms. Trail Registration ChiCTR2200055792, 2022.1.20, www.medresman.org.cn ; |
| first_indexed | 2024-04-09T14:06:04Z |
| format | Article |
| id | doaj.art-f6a3659da47a429ca1aebb73d9d3a512 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-09T14:06:04Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f6a3659da47a429ca1aebb73d9d3a5122023-05-07T11:04:49ZengBMCBMC Cardiovascular Disorders1471-22612023-05-012311810.1186/s12872-023-03246-3The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and designNan Nan0Lei Feng1Wei Dong2Bingyu Gao3Huijuan Zuo4Hongzhi Mi5Gang Wang6Xiantao Song7Hongjia Zhang8Department of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital, Advanced Innovation Center for Human Brain Protection, Capital Medical UniversityDepartment of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Community Health Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel DiseaseDepartment of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical UniversityThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital, Advanced Innovation Center for Human Brain Protection, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University; Beijing Lab for Cardiovascular Precision Medicine; Key Laboratory of Medical Engineering for Cardiovascular DiseaseAbstract Background Mental stress-induced myocardial ischemia (MSIMI) frequently occurs in patients with coronary artery disease (CAD), and is even more common in patients with co-occurring CAD and depression/anxiety. MSIMI appears to be a poor prognostic factor for CAD, but existing data on depression/anxiety patients are limited. Methods This cohort study will consecutively screen 2,647 CAD patients between 2023 and 2025. Included subjects will need to have received coronary revascularization and also have depression and/or anxiety at baseline. This study will enroll 360 subjects who meet the criteria. Two mental stress tests will be carried out in each patient at 1 month and 1 year timelines after coronary revascularization, using Stroop color word tests. MSIMI will be assessed by 99 m−Tc-sestamibi myocardial perfusion imaging. The endothelial function will be assessed by EndoPAT. Furthermore, we will dynamically monitor patients’ health and mental conditions every 3 months. The mean follow-up time will be 1 year. The primary endpoint is the major adverse cardiac events, a composite of all-cause death, cardiac death, myocardial infarction, stroke, or unplanned revascularization. Secondary endpoints will include overall health and mental conditions. The reproducibility of mental stress combined with myocardial perfusion for detecting MSIMI and comparisons between coronary stenosis and ischemic segments will also be included. Conclusions This cohort study will provide information on MSIMI outcomes in CAD patients who also have comorbid depression/anxiety after revascularization. In addition, understanding the long-term dynamics of MSIMI and the match between coronary stenosis and ischemia will provide insight into MSIMI mechanisms. Trail Registration ChiCTR2200055792, 2022.1.20, www.medresman.org.cn ;https://doi.org/10.1186/s12872-023-03246-3Mental stress-induced myocardial ischemiaCoronary revascularizationMyocardial perfusion imagingEndothelial functionMajor adverse cardiac events |
| spellingShingle | Nan Nan Lei Feng Wei Dong Bingyu Gao Huijuan Zuo Hongzhi Mi Gang Wang Xiantao Song Hongjia Zhang The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and design BMC Cardiovascular Disorders Mental stress-induced myocardial ischemia Coronary revascularization Myocardial perfusion imaging Endothelial function Major adverse cardiac events |
| title | The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and design |
| title_full | The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and design |
| title_fullStr | The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and design |
| title_full_unstemmed | The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and design |
| title_short | The prognostic study of mental stress-induced myocardial ischemia in coronary revascularization patients with depression/anxiety: rationale and design |
| title_sort | prognostic study of mental stress induced myocardial ischemia in coronary revascularization patients with depression anxiety rationale and design |
| topic | Mental stress-induced myocardial ischemia Coronary revascularization Myocardial perfusion imaging Endothelial function Major adverse cardiac events |
| url | https://doi.org/10.1186/s12872-023-03246-3 |
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