Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease
Abstract Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in...
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Animal Models and Experimental Medicine |
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| Online Access: | https://doi.org/10.1002/ame2.12212 |
| _version_ | 1818986855829340160 |
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| author | Jie Zheng |
| author_facet | Jie Zheng |
| author_sort | Jie Zheng |
| collection | DOAJ |
| description | Abstract Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro‐neurogenic therapies including rescuing innate AHN, cell engraftment and glia‐neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neuronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro‐neurogenic remedies. |
| first_indexed | 2024-12-20T18:57:26Z |
| format | Article |
| id | doaj.art-f6a408da397740909bb732e76c78b36e |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-12-20T18:57:26Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-f6a408da397740909bb732e76c78b36e2022-12-21T19:29:29ZengWileyAnimal Models and Experimental Medicine2576-20952022-02-015131410.1002/ame2.12212Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's diseaseJie Zheng0Department of Pharmacology Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Guizhou Province Zunyi Medical University Zunyi ChinaAbstract Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro‐neurogenic therapies including rescuing innate AHN, cell engraftment and glia‐neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neuronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro‐neurogenic remedies.https://doi.org/10.1002/ame2.12212Alzheimer's diseasecognitive deficithippocampusneurogenesispro‐neurogenic therapy |
| spellingShingle | Jie Zheng Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease Animal Models and Experimental Medicine Alzheimer's disease cognitive deficit hippocampus neurogenesis pro‐neurogenic therapy |
| title | Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease |
| title_full | Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease |
| title_fullStr | Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease |
| title_full_unstemmed | Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease |
| title_short | Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease |
| title_sort | hippocampal neurogenesis and pro neurogenic therapies for alzheimer s disease |
| topic | Alzheimer's disease cognitive deficit hippocampus neurogenesis pro‐neurogenic therapy |
| url | https://doi.org/10.1002/ame2.12212 |
| work_keys_str_mv | AT jiezheng hippocampalneurogenesisandproneurogenictherapiesforalzheimersdisease |