Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review
ABSTRACT Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The disease is endemic in several regions of tropical and temperate climate. The fungus presents opportunistic behavior, causing widespread infection in immunocompromised patients, resulting from complicat...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2021-05-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100502&tlng=pt |
| _version_ | 1798015280188751872 |
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| author | Jéssica Mauricio Batista Maria Auxiliadora Parreiras Martins Caryne Margotto Bertollo |
| author_facet | Jéssica Mauricio Batista Maria Auxiliadora Parreiras Martins Caryne Margotto Bertollo |
| author_sort | Jéssica Mauricio Batista |
| collection | DOAJ |
| description | ABSTRACT Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The disease is endemic in several regions of tropical and temperate climate. The fungus presents opportunistic behavior, causing widespread infection in immunocompromised patients, resulting from complication of primary pulmonary infection, due to exogenous reinfection or reactivation of a quiescent source. In immunocompetent individuals, approximately 95% of pulmonary infections are asymptomatic. However, prolonged exposure to high amount spores may lead to acute or chronic lung infection. Due to the low amount of inoculum, primary cutaneous histoplasmosis caused by traumatic implantation is extremely rare and effectively treated with triazoles. Thus, the present study aims to report a case of primary cutaneous histoplasmosis that is difficult to treat in an immunocompetent patient, and to review the literature on the incidence of drug-resistant Histoplasma capsulatum strains in clinical practice. |
| first_indexed | 2024-04-11T15:31:56Z |
| format | Article |
| id | doaj.art-f6a40ada970e4dba9849e58de8818387 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-04-11T15:31:56Z |
| publishDate | 2021-05-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-f6a40ada970e4dba9849e58de88183872022-12-22T04:16:07ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852021-05-011910.31744/einstein_journal/2021rc5488Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature reviewJéssica Mauricio Batistahttps://orcid.org/0000-0003-1031-8736Maria Auxiliadora Parreiras Martinshttps://orcid.org/0000-0002-5211-411XCaryne Margotto Bertollohttps://orcid.org/0000-0002-4115-559XABSTRACT Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The disease is endemic in several regions of tropical and temperate climate. The fungus presents opportunistic behavior, causing widespread infection in immunocompromised patients, resulting from complication of primary pulmonary infection, due to exogenous reinfection or reactivation of a quiescent source. In immunocompetent individuals, approximately 95% of pulmonary infections are asymptomatic. However, prolonged exposure to high amount spores may lead to acute or chronic lung infection. Due to the low amount of inoculum, primary cutaneous histoplasmosis caused by traumatic implantation is extremely rare and effectively treated with triazoles. Thus, the present study aims to report a case of primary cutaneous histoplasmosis that is difficult to treat in an immunocompetent patient, and to review the literature on the incidence of drug-resistant Histoplasma capsulatum strains in clinical practice.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100502&tlng=ptHistoplasmosisHistoplasmaImmunocompetenceItraconazole |
| spellingShingle | Jéssica Mauricio Batista Maria Auxiliadora Parreiras Martins Caryne Margotto Bertollo Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review Einstein (São Paulo) Histoplasmosis Histoplasma Immunocompetence Itraconazole |
| title | Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review |
| title_full | Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review |
| title_fullStr | Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review |
| title_full_unstemmed | Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review |
| title_short | Primary cutaneous histoplasmosis difficult to treat in immunocompetent patient: case report and literature review |
| title_sort | primary cutaneous histoplasmosis difficult to treat in immunocompetent patient case report and literature review |
| topic | Histoplasmosis Histoplasma Immunocompetence Itraconazole |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100502&tlng=pt |
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